Results 21 to 30 of about 9,792 (172)

The Kinase Specificity of Protein Kinase Inhibitor Peptide

Frontiers in Pharmacology, 2021
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
doaj   +1 more source

PKI-587 blocked PI3K/AKT/mTOR induced by radiation and inhibited DNA damage repair pathway when combined with radiation in vivo.

, 2021
(A and B) Western blot assay and semiquantitative analysis of the levels of PI3Kp110α, p-Akt (Ser473), Akt, p-mTOR (Ser2448), and mTOR proteins involved in the PI3K/AKT/mTOR pathway in SK-Hep1 cells after radiation and PKI-587 alone or in combination for
Yinghai Xie (11581557), Yinci Zhang (5417780), Rui Li (4631), Chong Sun (2134873), Amin Li (1960315), Yingru Xing (11581560), Qi Wang (22418), Minghong Shi (10987266), Changwei Liu (631801)   +8 more
core   +1 more source

Research on Application of Blockchain in PKI Security [PDF]

Jisuanji kexue yu tansuo
The design idea of emphasizing application and neglecting defense leads to the lack of endogenous security attributes at the beginning of the design of transmission control protocol/Internet protocol (TCP/IP) architecture. Public key infrastructure (PKI),
XIA Lingling, WANG Qun, MA Zhuo, LIANG Guangjun
doaj   +1 more source

Ahmad Tohari’s The dancer: Revisited

K@ta: A Biannual Publication on the Study of Language and Literature, 2017
As with many post-colonial countries, Indonesia has suffered from a long conflict between the military and civil society since its independence in 1945. This struggle is reflected in Ahmad Tohari’s novel entitled The dancer (2012), which has been largely
Dwi Setiawan
doaj   +1 more source

PKI-587 enhances radiosensitization of hepatocellular carcinoma by inhibiting the PI3K/AKT/mTOR pathways and DNA damage repair.

PLoS ONE, 2021
Radiation is an important therapeutic strategy for hepatocellular (HCC). In this study, we evaluated the role of the dual PI3K/mTOR inhibitor, PKI-587, on radiosensitization of HCC and its possible mechanism.
Yinghai Xie, Changwei Liu, Yinci Zhang, Amin Li, Chong Sun, Rui Li, Yingru Xing, Minghong Shi, Qi Wang   +8 more
doaj   +1 more source

On the Practicality of a Smart Contract PKI [PDF]

2019 IEEE International Conference on Decentralized Applications and Infrastructures (DAPPCON), 2019
Public key infrastructures (PKIs) are one of the main building blocks for securing communications over the Internet. Currently, PKIs are under the control of centralized authorities, which is problematic as evidenced by numerous incidents where they have been compromised.
Christos Patsonakis, Katerina Samari, Aggelos Kiayias, Mema Roussopoulos   +3 more
openaire   +3 more sources

PKI-587 combined with IR promoted G0/G1 phase cell arrest in SK-Hep1 cells.

, 2021
(A and B) Cell-cycle distribution in SK-Hep1 cells as determined with flow cytometry after IR (2 Gy) alone or combined with PKI-587 (0.1 μM) treatment for 24 h.
Yinghai Xie (11581557), Yinci Zhang (5417780), Rui Li (4631), Chong Sun (2134873), Amin Li (1960315), Yingru Xing (11581560), Qi Wang (22418), Minghong Shi (10987266), Changwei Liu (631801)   +8 more
core   +1 more source

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

eLife, 2020
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia   +13 more
doaj   +1 more source

DINAMIKA KONFLIK ANTARA PERSATUAN GURU REPUBLIK INDONESIA DAN PARTAI KOMUNIS INDONESIA

Istoria, 2020
ABSTRAK Persatuan Guru Republik Indonesia atau disingkat PGRI merupakan wadah organisasi yang menampung semua guru di Indonesia. PGRI memiliki peran yang sangat penting dalam pendidikan, terutama dalam perbaikan kualitas guru di Indonesia.
Angga Angga Prasetiyo
doaj   +1 more source

EKSISTENSI GUA UMBULTUK SEBAGAI PERSEMBUNYIAN SISA-SISA G30S/PKI

, 2023
Dalam sejarahnya, PKI memiliki banyak pergolakan dan pengorbanan yang dialami. Dari tahun ke tahun PKI seringkali berupaya untuk melakukan pemberontakan terhadap pemerintahan Indonesia.
Manasikana, Arina, Putranto, Anggoro, Wulandari, Ulfa Dwi   +2 more
core   +1 more source