Results 41 to 50 of about 9,898 (182)
The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites
ERJ Open Research, 2018 Ivacaftor–lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two metabolites hydroxymethylivacaftor (iva-M1) and ivacaftorcarboxylate (iva-M6) with ...
Elena K. Schneider +10 more
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Kinematic‐calcium loops unravel impaired excitation–contraction coupling in MELAS‐affected cardioids
The Journal of Physiology, EarlyView.Abstract figure legend Representation of kinematic and calcium transient loop with respect to traditional time coplotting. Abstract Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart.
Margherita Burattini +7 more
wiley +1 more source
Bihdād, 2020 Preventing and reducing the spread of HIV (HIV) has always been a concern in medical science. One of the most common ways to control the virus is using enzyme-blocking drugs. In this study, we attempted to predict the biological activity (PKi) of organic
Zakiyeh Bayat +1 more
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Insights into factorless translational initiation by the tRNA-like pseudoknot domain of a viral IRES. [PDF]
PLoS ONE, 2012 The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae family adopts an overlapping triple pseudoknot structure to directly recruit the 80S ribosome in the absence of initiation factors.
Hilda H T Au, Eric Jan
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Unchained voices: Exploring incarcerated women's pathways to restorative justice
Legal and Criminological Psychology, Volume 31, Issue 2, Page 333-347, September 2026.Abstract Purpose Restorative justice (RJ) is an approach to justice that focuses on repairing the harm caused by criminal offences through dialogue, accountability and reparation. Despite its growing recognition, the implementation of RJ programmes within prison settings remains limited, particularly in women's prisons.
Inbal Peleg‐Koriat +1 more
wiley +1 more source
A Human Rights Perspective on Granting Privileges to Descendants of PKI in Indonesia
Fiat JustisiaHuman rights, as inherent rights granted to all individuals by virtue of their existence, are enshrined in Law Number 39 of 1999 concerning Human Rights.
Susi Susantijo
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POSTMEMORY DALAM NOVEL TAPOL KARYA NGARTO FEBRUANA
Jurnal Poetika, 2019 Narasi balas dendam yang masih terus direproduksi oleh pihak-pihak yang bertikai semakin membuat rekonsiliasi tragedi ’65 berujung pada kemacetan. Kerelaan untuk sa-ling mengakui kesalahan adalah langkah besar dalam usaha rekonsiliasi.
Anna Elfira Prabandari Assa
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Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. [PDF]
PLoS ONE, 2011 cAMP-dependent protein kinase (PKA) has been implicated in the asexual stage of the Toxoplasma gondii life cycle through assaying the effect of a PKA-specific inhibitor on its growth rate. Since inhibition of the host cell PKA cannot be ruled out, a more
Hitomi Kurokawa +10 more
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Archiv der Pharmazie, Volume 359, Issue 8, August 2026.From a synthesized series of 2,4‐diaminoquinazoline‐type Y5R ligands, three were prepared as tritium‐labeled compounds and characterized by saturation equilibrium binding at HEC‐1B‐hY5R cells. [3H]32 was further applied in a competition binding assay. High non‐specific binding of the radioligands prompted investigation of material‐dependent adsorption.
Franziska Schettler +2 more
wiley +1 more source
Practical Implementation of Various Public Key Infrastructure Models
Безопасность информационных технологий, 2016 The paper proposes a short comparative analysis of the contemporary models of public key infrastructure (PKI) and the issues of the PKI models real implementation. The Russian model of PKI is presented.
Dmitriy Anatolievich Melnikov +3 more
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