Results 51 to 60 of about 64,904 (211)
A Semi-Decentralized PKI Based on Blockchain With a Stake-Based Reward-Punishment Mechanism
IEEE AccessThe conventional Public Key Infrastructure (PKI) has long been plagued by security issues stemming from its centralized and non-transparent design. In recent years, blockchain-based PKI architectures have emerged as promising solutions to overcome such ...
Erhan Turan, Sevil Sen, Tamer Ergun
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Cancer Science, Volume 117, Issue 5, Page 1273-1285, May 2026.Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut +13 more
wiley +1 more source
Enabling Secure Database as a Service using Fully Homomorphic Encryption: Challenges and Opportunities [PDF]
, 2013 The database community, at least for the last decade, has been grappling with querying encrypted data, which would enable secure database as a service solutions.
Gunda, Manikanta +2 more
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The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites
ERJ Open Research, 2018 Ivacaftor–lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two metabolites hydroxymethylivacaftor (iva-M1) and ivacaftorcarboxylate (iva-M6) with ...
Elena K. Schneider +10 more
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Transformative Learning for Controversial History of G 30 S/PKI
Paramita: Historical Studies Journal, 2020 G 30 S/PKI is a controversial issue in Indonesian history and a sensitive material because of past traumatic memories. It is a challenge for history teachers in learning in schools.
Yudi Hartono, Khoirul Huda
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JMIR Research Protocols, 2021 BackgroundThe strengthening or substitution of intravenous cytotoxic chemotherapy cycles by oral targeted anticancer therapies, such as protein kinase inhibitors (PKIs), has provided impressive clinical benefits and autonomy as well as a better quality ...
Carole Bandiera +20 more
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Struktureller Mechanismus eines Aktivitäts‐Photoschalters am β2‐adrenergen Rezeptor
Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.Zeitaufgelöste Strukturen aus Messungen an Röntgen‐Freie‐Elektronen‐Lasern in Kombination mit zellulären Assays zeigen, wie der photoschaltbare β‐Blocker Photoazolol‐1 als Wirksamkeits‐Photoschalter der Funktion des β2‐adrenergen Rezeptor wirkt. Die lichtinduzierte Neupositionierung des Liganden verschiebt die Aktivität von inversem Agonistimus hin zu ...
Robin Stipp +29 more
wiley +1 more source
Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component [PDF]
, 1996 The Ki-67 antigen is detected in proliferating cells in all phases of the cell division cycle. Throughout most of interphase, the Ki-67 antigen is localised within the nucleolus.
Kill, IR
core
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
Bihdād, 2020 Preventing and reducing the spread of HIV (HIV) has always been a concern in medical science. One of the most common ways to control the virus is using enzyme-blocking drugs. In this study, we attempted to predict the biological activity (PKi) of organic
Zakiyeh Bayat +1 more
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