Results 71 to 80 of about 64,904 (211)

Altered functional interactions between CFTR disease mutants ΔF508 and G551D and the protein kinase A catalytic subunit

The Journal of Physiology, Volume 604, Issue 8, Page 3344-3362, 15 April 2026.
Abstract figure legend Pathogenic mutations ΔF508 and G551D of the cystic fibrosis transmembrane conductance regulator (CFTR) channel alter its interactions with protein kinase A (PKA). Top left, for both mutants, but not for wild‐type (WT) CFTR, non‐catalytic stimulation of channel activity by PKA is larger in the presence of N6‐(2‐phenylethyl)‐ATP (P‐
Olivér Závoti, Márton A. Simon, László Csanády   +2 more
wiley   +1 more source

Debridement, antibiotics, and implant retention for periprosthetic knee infections: a pooling analysis of 1266 cases

Journal of Orthopaedic Surgery and Research, 2019
Background The debridement, antibiotics, and implant retention (DAIR) procedure is an established therapeutic option for periprosthetic knee infections (PKI). However, the efficacy and the indication for this procedure are still controversial.
Guo-Xin Qu, Cai-Hua Zhang, Shi-Gui Yan, Xun-Zi Cai   +3 more
doaj   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

A Game-Theoretic Approach to Energy-Efficient Resource Allocation in Device-to-Device Underlay Communications [PDF]

, 2014
Despite the numerous benefits brought by Device-to-Device (D2D) communications, the introduction of D2D into cellular networks poses many new challenges in the resource allocation design due to the co-channel interference caused by spectrum reuse and ...
Dong, Mianxiong, Liu, Zhiheng, Ota, Kaoru, Sato, Takuro, Shi, Ruifeng, Zhou, Zhenyu   +5 more
core  

KETIKA KEBIJAKAN ORDE LAMA MEMASUKI DOMAIN PENDIDIKAN: PENYIAPAN DAN KINERJA GURU SEKOLAH DASAR DI INDONESIA

Paramita: Historical Studies Journal, 2014
This article reveals how the educational policy in Indonesia during The Old Order. The domination of government (Soekarno) as expressed in the domination theory by Antonio Gramsci which a politic is a commander and it can dominate whole Indonesia society
Umasih Umasih
doaj   +1 more source

Human vs. artificial intelligence: Physicians outperform ChatGPT in real‐world pharmacotherapy counselling

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 891-902, March 2026.
Aims To assess the utility of the artificial intelligence (AI) chatbot ChatGPT (openly available version 3.5) in responding to real‐world pharmacotherapeutic queries from healthcare professionals. Methods Three independent and blinded evaluators with different levels of medical expertise and professional experience (beginner, advanced, and expert ...
Benjamin Krichevsky, Stefan Engeli, Stefanie M. Bode‐Böger, Felix Koop, Martin Schulze Westhoff, Sebastian Schröder, Carsten Schumacher, Thorben Pape, Dirk O. Stichtenoth, Johannes Heck   +9 more
wiley   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

Matrix powers algorithms for trust evaluation in PKI architectures [PDF]

, 2012
This paper deals with the evaluation of trust in public-key infrastructures. Different trust models have been proposed to interconnect the various PKI components in order to propagate the trust between them.
Dumas, Jean-Guillaume, Hossayni, Hicham
core   +2 more sources

Positive Essentialization Reduces Prejudice: Reminding Participants of a Positive Human Nature Alleviates the Stigma of Indonesian Communist Party (PKI) Descent

Journal of Social and Political Psychology, 2018
This study aims to demonstrate and change negative perceptions of descendants of members of the Indonesian Communist Party (Partai Komunis Indonesia/PKI), a stigmatized social group in Indonesia.
Idhamsyah Eka Putra, Peter Holtz, Ardiningtiyas Pitaloka, Nicole Kronberger, Nurul Arbiyah   +4 more
doaj   +1 more source

Europium Metal Complex [Eu(dbm)3.LAP] Promotes Antinociceptive Behavior via TRPA1 Neuromodulation and an Anti‐Inflammatory Effect in Adult Zebrafish

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
The [Eu(dmb)3.LAP] complex was synthesized and characterized as a potent neuromodulatory and anti‐inflammatory agent. Molecular docking and ADMET analyses revealed a candidate that is permeable to the brain barrier and targets TRPA1 receptors. In vivo assays using adult zebrafish confirmed a significant reduction in inflammatory responses, highlighting
Emanuela de Lima Rebouças Borges, Antonio Wlisses da Silva, Erick Patrick Alves Moreira, Matheus Nunes da Rocha, Hélcio Silva dos Santos, Jorge Fernando Silva de Menezes, Aluísio Marques da Fonseca, Maria Izabel Florindo Guedes, Emmanuel Silva Marinho   +8 more
wiley   +1 more source