Results 61 to 70 of about 9,898 (182)

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1744-1759, June 2026.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Probability References to Apply in the Detection of Anomalous Public Key Infrastructures

Journal of Computer Science and Technology, 2016
This article calculates the theoretical probability of finding repeated primes in a given sample of unbiased issued digital certificates. These values can be used as reference for developing a statistical procedure to audit and control the behavioral ...
Antonio Castro Lechtaler, Marcelo Cipriano, Eduardo Malvacio   +2 more
doaj  

Deleterious association between proton pump inhibitor and protein kinase inhibitor exposure and survival for patients with lung cancer: A nationwide cohort study

Cancer Treatment and Research Communications
Introduction: Previous studies have identified an interaction between protein kinase inhibitors (PKIs) and proton pump inhibitors (PPIs) in patients with lung cancer. This type of interaction may reduce the efficacy of PKIs.
Constance Bordet, Mahmoud Zureik, Yoann Zelmat, Margaux Lafaurie, Maryse Lapeyre-Mestre, Agnès Sommet, Julien Mazieres, Fabien Despas   +7 more
doaj   +1 more source

Model for PKI interoperability in Serbia / Модель доверия и архетектура PKI в Республике Сербия / Model za PKI interoperabilnost u Republici Srbiji

Vojnotehnički Glasnik, 2017
The increasing use of electronic services that use electronic certificates and the increasing implementation of public key infrastructures require their interconnection and interoperability.
Radomir I. Prodanović, Ivan B. Vulić
doaj   +1 more source

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells

Frontiers in Pharmacology, 2017
Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags.
Maria Augusta Arruda, Maria Augusta Arruda, Maria Augusta Arruda, Leigh A. Stoddart, Leigh A. Stoddart, Karolina Gherbi, Karolina Gherbi, Stephen J. Briddon, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill, Stephen J. Hill   +11 more
doaj   +1 more source

PERANAN SURAT KABAR SOERAPATI DALAM PERLAWANAN INTELEKTUAL PRIBUMI DI JAWA BARAT TAHUN 1923-1925

Patanjala: Jurnal Penelitian Sejarah dan Budaya, 2016
Abstrak Perlawanan intelektual pribumi yang dilakukan oleh organisasi berideologi komunis menggunakan beberapa media, diantaranya surat kabar Soerapati. Metode yang digunakan adalah metode sejarah yang terdiri atas empat tahapan kerja: heuristik, kritik,
Dharyanto Tito Wardani
doaj   +1 more source

Triskelion—In Pursuit of Proficiency Through Immersive Gameplay

Information
As technology advances, interest in video games is extending to broader audiences. This makes gamification as a mechanism for improving educational outcomes increasingly attractive.
Victor Winter
doaj   +1 more source

PENELITIAN STUDI KASUS FENOMENOLOGI PERSEPSI KEADILAN PELAKU PEMBUNUHAN ANGGOTA PKI 1965

Jurnal Sains Psikologi, 2017
Penelitian ini bertujuan untuk mendeskripsikan persepsi keadilan pelaku pembunuhan anggota PKI tahun 1965. Rancangan penelitian yang digunakan adalah kualitatif dengan model studi kasus fenomenologi.
Kukuh Setyo Pambudi, Indah Yasminum Suhanti   +1 more
doaj  

Esquema de confianza basado en Infraestructura de clave pública (PKI) para el intercambio de información clínica electrónica en el sistema XAVIA HIS

Revista Cubana de Informática Médica, 2020
La seguridad informática se ha convertido en una necesidad y un derecho de todos los ciudadanos. Los sistemas informáticos empleados en el sector de salud poseen un almacenamiento digital fácil y sostenible que debe  garantizar la privacidad e integridad
Yanssel Urquijo Morales, Arturo Orellana García   +1 more
doaj