Results 221 to 230 of about 60,739 (253)
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Biochemical Pharmacology, 2020
AIMS Protein Kinase R (PKR) plays a key role in inflammation and insulin resistance. Cytokines, high fat diet, infection and various stress signals can activate PKR.
Sureshbabu Mangali +6 more
semanticscholar +1 more source
AIMS Protein Kinase R (PKR) plays a key role in inflammation and insulin resistance. Cytokines, high fat diet, infection and various stress signals can activate PKR.
Sureshbabu Mangali +6 more
semanticscholar +1 more source
Proteins that interact with PKR
Biochimie, 1994The in vitro activities of recombinant gene products of the vaccinia virus E3L and K3L genes have been compared. These proteins are both potent inhibitors of the dsRNA activated protein kinase (PKR) as assayed in cell-free translation systems or with purified PKR. The two gene products function at similar molar concentrations.
R, Jagus, M M, Gray
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Science's STKE, 2000
Double-stranded RNA (dsRNA) is detected by cells and triggers several different cellular responses. These pathways are important for controlling viral infections in the host and include stimulation of apoptosis to prevent spread of the virus, inhibition of protein synthesis to prevent viral replication, and induction of antiviral ...
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Double-stranded RNA (dsRNA) is detected by cells and triggers several different cellular responses. These pathways are important for controlling viral infections in the host and include stimulation of apoptosis to prevent spread of the virus, inhibition of protein synthesis to prevent viral replication, and induction of antiviral ...
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Science's STKE, 2001
The vital role of interferons (IFNs) as mediators of innate immunity is well established. It has recently become apparent that one of the pivotal proteins in mediating the antiviral activity of IFNs, the double-stranded RNA (dsRNA)-activated protein kinase (PKR), also functions as a signal transducer in the proinflammatory response to ...
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The vital role of interferons (IFNs) as mediators of innate immunity is well established. It has recently become apparent that one of the pivotal proteins in mediating the antiviral activity of IFNs, the double-stranded RNA (dsRNA)-activated protein kinase (PKR), also functions as a signal transducer in the proinflammatory response to ...
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PKR suppress NLRP3-pyroptosis pathway in lipopolysaccharide-induced acute lung injury model of mice.
Biochemical and Biophysical Research Communications - BBRC, 2019To explore the effect of double-stranded RNA-dependent kinase (PKR) in acute lung injury (ALI) and resultant acute respiratory distress syndrome (ARDS).
Yanjun Zeng +12 more
semanticscholar +1 more source
Neuroscience, 2019
The chronic neuropathic pain-associated psychiatric disorders have seriously disturbed the quality of patients' life, such as depression and anxiety.
Qian Li +7 more
semanticscholar +1 more source
The chronic neuropathic pain-associated psychiatric disorders have seriously disturbed the quality of patients' life, such as depression and anxiety.
Qian Li +7 more
semanticscholar +1 more source
Biochemical and Biophysical Research Communications - BBRC, 2019
nc886, a long non-coding RNA (ncRNA) of 101 nucleotides in length, is known as a vault RNA or microRNA precursor. Despite the recent discovery that ncRNAs in the nucleus play a crucial role in regulating chromosomal transformation and transcription, only
Kwang-Soo Lee +9 more
semanticscholar +1 more source
nc886, a long non-coding RNA (ncRNA) of 101 nucleotides in length, is known as a vault RNA or microRNA precursor. Despite the recent discovery that ncRNAs in the nucleus play a crucial role in regulating chromosomal transformation and transcription, only
Kwang-Soo Lee +9 more
semanticscholar +1 more source
Archives of Biochemistry and Biophysics, 2015
Tyrosine phosphorylation of insulin receptor beta (IRβ) in insulin treated HepG2 cells is inversely correlated to ser(51) phosphorylation in the alpha-subunit of eukaryotic initiation factor 2 (eIF2α) that regulates protein synthesis. Insulin stimulates interaction between IRβ and PKR, double stranded RNA-dependent protein kinase, also known as EIF2AK2,
Medchalmi Swetha, Kolluru V.A. Ramaiah
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Tyrosine phosphorylation of insulin receptor beta (IRβ) in insulin treated HepG2 cells is inversely correlated to ser(51) phosphorylation in the alpha-subunit of eukaryotic initiation factor 2 (eIF2α) that regulates protein synthesis. Insulin stimulates interaction between IRβ and PKR, double stranded RNA-dependent protein kinase, also known as EIF2AK2,
Medchalmi Swetha, Kolluru V.A. Ramaiah
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Journal of Interferon & Cytokine Research, 1999
The interferon (IFN)-induced, double-stranded RNA (dsRNA)-activated human protein kinase (PKR) has been shown to exert antiviral and antiproliferative effects. Activation of the enzyme in mammalian cells results in protein synthesis inhibition and cell death by apoptosis. Previous studies on the structure-function relationship of PKR have been based on
C, Rivas, J, Gil, M, Esteban
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The interferon (IFN)-induced, double-stranded RNA (dsRNA)-activated human protein kinase (PKR) has been shown to exert antiviral and antiproliferative effects. Activation of the enzyme in mammalian cells results in protein synthesis inhibition and cell death by apoptosis. Previous studies on the structure-function relationship of PKR have been based on
C, Rivas, J, Gil, M, Esteban
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A role for PKR in hematologic malignancies
Journal of Cellular Physiology, 2010AbstractThe double‐stranded RNA‐dependent kinase PKR has been described for many years as strictly a pro‐apoptotic kinase. Recent data suggest that the main purpose of this kinase is damage control and repair following stress and, if all else fails, apoptosis.
Blalock WL +4 more
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