Results 111 to 120 of about 13,877,329 (284)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Using π0’s to Understand Proton Spin Structure through Polarized p+p Collisions at 1 \u3c η \u3c 2 and √s = 200 GeV at STAR [PDF]
, 2014 Measurements of spin dependent observables at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory provide unique insight into the contribution of a proton\u27s constituents to its spin.
Place, Stephen
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Usability Testing: Open GeoPortal 2.0 [PDF]
, 2014 The PLACE project team at the University of New Hampshire Library performed usability testing on May 9, 2014 with three participants with GIS experience. Tasks focused on use of Open GeoPortal 2.0 (beta)
Parker, Kristin, Wolff, Rob
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
PLACE: PRESENCE AS SECOND-PERSONAL SPACE
تأملات اخلاقی, 2020 The concept of place is ultimately a matter of ethical significance—of where something fits in a nexus or structure of meaning. Often this meaning is quite personal, involving a sense of presence we associate with a place.
Stephen Darwall
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Neutral Pion Asymmetries at Intermediate Pseudorapidity in Transversely Polarized p + p Collisions at √ s = 200 GeV [PDF]
, 2014 Among the unanswered questions pertaining to nucleon spin physics is the origin of large azimuthal asymmetries (AN ) found in π forward pseudorapidity, η, from high-energy transversely polarized p + p collisions.
Brandt, Samuel +2 more
core +1 more source
, 2018 An important endeavor in computer science is to understand the expressive power of logical formalisms over discrete structures, such as words. Naturally, "understanding" is not a mathematical notion.
Place, Thomas, Zeitoun, Marc
core +1 more source