Results 61 to 70 of about 881,114 (263)

The Place of Oral History in Archives Management [PDF]

open access: yesتحقیقات کتابداری و اطلاع‌رسانی دانشگاهی, 2008
Purpose: This paper considers the concept and background of oral history in internal and external references. Also it studies necessity, importance and agents of arising and developing oral history in the field of archives.
Majid Sabzipoor
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Place Branding as Efficient Management Tool for Local Government

open access: yesTransylvanian Review of Administrative Sciences, 2013
The economic liberalism, globalization and more recently the economic crisis are general phenomena leading to changes of territorial management practices.
Rodica PETREA   +3 more
doaj   +2 more sources

Historical Account of Managing Overabundant Wild Asian Elephants in Myanmar by the Kheddah System of Capture: Philosophy, Principles and Practices

open access: yesAnimals
When standard methods of human–elephant conflict mitigation are not successful, free-ranging wild elephants may continue to come into close contact with people.
Khyne U. Mar
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A Place for Nurses in Health Service Management?

open access: yesNursing Praxis in Aotearoa New Zealand, 1989
Professional advice is a load of hogwash ...'So says an anonymous regional manager of the British National health Service (NHS) in an interview reported by researchers Philip Strong and Jane Robinson in the September 1988 issue of the Nursing Times.
Joy Bickley RGON
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

From Networking to Attitudinal Outcomes: Psychological Capital as a Mediator

open access: yesPsychologica Belgica
Building on conservation of resources (COR) theory and following recent recommendations, this study investigates the mediating role of Psychological Capital (PsyCap) in the relationships between networking behaviors and attitudinal outcomes (i.e., work ...
Rachel Huynen   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

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