Results 111 to 120 of about 12,798,938 (311)

Improving network management efficiency : knowledge level granulation and fuzzy representation

open access: yes, 2010
Modern system management needs the capabilities to deal with a combination of areas, ranging from administration of elements to provision of services and management of the enterprise itself. As such, traditional element-based network management views are
Shahrestani, Seyed A. (R10567)
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Instructor interview for Place-Based WAC/WID writing instruction in Management, clip 7 of 13

open access: yes, 2015
This item includes a segment of an an instructor interview in a Writing Intensive course in Management at the University of Hawaiʻi at Mānoa. The interview was conducted in 2013 and in this clip the interviewee is discussing how to balance research and ...
Place-based WAC/WID Hui
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Student interview for Place-Based WAC/WID writing instruction in English, clip 3 of 16

open access: yes, 2015
This item includes a segment of a student interview in a Writing Intensive course in English at the University of Hawaiʻi at Mānoa. The interview was conducted in 2014, and in this clip the interviewee is responding to the question 'In responding to your
Place-based WAC/WID Hui
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Student interview for Place-Based WAC/WID writing instruction in Management, clip 14 of 14

open access: yes, 2015
This item includes a segment of an a student interview in a Writing Intensive course in Management at the University of Hawaiʻi at Mānoa. The interview was conducted in 2013 and in this clip the interviewee is describing writing in Korean.Brief excerpt ...
Place-based WAC/WID Hui
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

FinTech capability and systemic risk in banking

open access: yesInternational Review of Economics & Finance
This study examines whether banks' financial technology (fintech) engagement contributes to systemic financial stability and through which channel such effects materialize.
Zhe Fan, Lianmei Zhu
doaj   +1 more source

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