Results 111 to 120 of about 3,209,521 (303)

Collaboration Achieves Effective Waste Management Design at Brookfield Place Perth, Western Australia

Procedia Engineering, 2017
Abstract Waste management in commercial buildings is a critical factor in urban sustainability and is an important element in achieving green building certification. For instance, Green Building Council of Australia's (GBCA) Green Star rating tools include credit points for waste management.
Margaret Gollagher, Jenny Campbell, Anne-Marie Bremner   +2 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Improving the implementation of regulation: time for a systemic approach [PDF]

, 2014
The importance of an ‘efficient and effective regulatory environment’ (Offices of the Ministers of Finance and Regulatory Reform, 2013) has never been more prominent in New Zealand than it is at the present time. The New Zealand Productivity Commission’s
Keith Manch
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Community Perceptions Towards Temporary Waste Storage Place and the Effectiveness of Waste Management in Malang City

Jurnal Ilmu Lingkungan
Waste generated due to population density in Malang City causes the need for optimal and planned temporary waste storage place (TWSP) that can reduce waste properly so as not to endanger health.
Samin Samin, Sunarto Sunarto
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Efficient Resource Management Mechanism for 802.16 Wireless Networks Based on Weighted Fair Queuing [PDF]

, 2008
Wireless Networking continues on its path of being one of the most commonly used means of communication. The evolution of this technology has taken place through the design of various protocols.
Rangula, Kiran
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Place-based drivers and effective management of population growth and change in regional Australia

AHURI Final Report
This study examines the place-based factors (i.e. that may be specific to a place) that influence people moving to and from Australian regional and rural areas and considers policy solutions for managing the impacts of this change.People moving to regional cities and towns favour being close to the coast and having easy access to larger cities while ...
Caitlin Buckle, Greta Werner, Nancy Marshall, Glen Searle, Nick Osbaldiston, Somwrita Sarkar, Durba Kundu, Nicole Gurran, Jen Arnold   +8 more
openaire   +2 more sources