Results 201 to 210 of about 677,625 (318)

Survival benefit of oral systemic monotherapy in previously treated metastatic colorectal cancer: a meta-analysis. [PDF]

Oncologist
Pfeiffer P, Cremolini C, Ducreux M, Osterlund P, Ronnebaum S, Akin-Fajiye M, Paly V, Hernandez L, Elez E.   +8 more
europepmc   +1 more source

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

SAY NO TO PLACEBOS

AJN, American Journal of Nursing, 1994
Margo McCaffery, Betty R. Ferrell
openaire   +2 more sources

Effects of mulberry leaves & water chestnut husk tea on postprandial and second meal interstitial glucose in healthy adults: A randomised, double-blind, placebo-controlled crossover study. [PDF]

Asia Pac J Clin Nutr
Yasutake K, Agune M, Yasuda M.
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Tirzepatide and the Cardiovascular Continuum: Metabolic, Cardiorenal and Heart Failure Evidence. [PDF]

Clin Med Insights Cardiol
Parlati AL, Martini L, Nardi E, Carluccio R, Parlati LE, Madaudo C, Perrone Filardi P.   +6 more
europepmc   +1 more source

The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response

Nicholas J Bush,1,2 Adriana K Cushnie,2 Jeff Boissoneault,1,2 Sharmagh Aghabeigi,1 Casey Alexander,1 Roland Staud,3 Michael E Robinson1 1Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; 2Department of ...
Robinson ME, Boissoneault J, Bush NJ, Alexander C, Staud R, Aghabeigi S, Cushnie AK   +6 more
core  

Pharmacokinetics, safety, tolerability and fluorescence imaging of nizaracianine triflutate administered in three divided doses to healthy volunteers

British Journal of Clinical Pharmacology, EarlyView.
Aim Fluorescence‐guided surgery enhances intraoperative visualization of anatomical structures. Nizaracianine is a near‐infrared fluorescent agent that is exclusively renally cleared in animal models. It enables real‐time ureteral imaging and identification, potentially reduces risk of injury and facilitates assessment before surgical closure.
Lisanne K. A. Neijenhuis, Cedric M. W. Pesch, John V. Frangioni, Alexander L. Vahrmeijer, Jacobus Burggraaf, Naomi B. Klarenbeek   +5 more
wiley   +1 more source

Pharmacological aspects of placebo effect

Thesis on placebo effects in different aspects such as physiological, neurological, and psychological. In addition, a review of the ethical issues involving the use of placebos.egységes, osztatlanáltalános ...
Zucker, Guy
core  

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source