Results 21 to 30 of about 1,543,966 (410)

Lack of Effects of the Presence of a Dog on Pain Perception in Healthy Participants—A Randomized Controlled Trial

Frontiers in Pain Research, 2021
Animal-assisted interventions (AAIs) have been shown to be effective in the treatment of pain. Studies suggest that relationships with animals can have comparable qualities to relationships with humans and that this enables animals to provide social ...
Cora Wagner, Jens Gaab, Cosima Locher, Cosima Locher, Cosima Locher, Karin Hediger, Karin Hediger, Karin Hediger, Karin Hediger   +8 more
doaj   +1 more source

Pembrolizumab or Placebo Plus Etoposide and Platinum as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: Randomized, Double-Blind, Phase III KEYNOTE-604 Study.

Journal of Clinical Oncology, 2020
PURPOSE Pembrolizumab monotherapy has shown antitumor activity in patients with small-cell lung cancer (SCLC). The randomized, double-blind, phase III KEYNOTE-604 study compared pembrolizumab plus etoposide and platinum (EP) with placebo plus EP for ...
C. Rudin, M. Awad, A. Navarro, M. Gottfried, S. Peters, T. Csőszi, P. Cheema, D. Rodríguez-Abreu, M. Wollner, J. Yang, J. Mazières, F. Orlandi, A. Luft, M. Gumus, T. Kato, G. Kalemkerian, Yi Luo, V. Ebiana, M. Pietanza, H. R. Kim, Keynote Investigators   +20 more
semanticscholar   +1 more source

The Ethics of Placebo-controlled Trials: Methodological Justifications [PDF]

, 2013
The use of placebo controls in clinical trials remains controversial. Ethical analysis and international ethical guidance permit the use of placebo controls in randomized trials when scientifically indicated in four cases: (1) when there is no proven ...
Grady, Christine, Millum, Joseph
core   +1 more source

Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial

Trials, 2017
Background Placebo medications, by definition, are composed of inactive ingredients that have no physiological effect on symptoms. Nonetheless, administration of placebo in randomized controlled trials (RCTs) and in clinical settings has been ...
Sarah Ballou, Ted J. Kaptchuk, William Hirsch, Judy Nee, Johanna Iturrino, Kathryn T. Hall, John M. Kelley, Vivian Cheng, Irving Kirsch, Eric Jacobson, Lisa Conboy, Anthony Lembo, Roger B. Davis   +12 more
doaj   +1 more source

Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes [PDF]

, 2017
Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors may reduce cardiovascular and heart failure risk in patients with type 2 diabetes mellitus (T2DM).
Butler, Javed, Davies, Michael J., Desai, Mehul, Januzzi, James L., Jarolim, Petr, Sattar, Naveed, Vijapurkar, Ujjwala   +6 more
core   +1 more source

Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia

Frontiers in Psychiatry, 2021
The idea that maladaptive memories may be rendered susceptible to interference after reactivation raises the possibility of reactivating and neutralizing clinically-relevant emotional memories.
James W. B. Elsey, Merel Kindt
doaj   +1 more source

Post-Depletion Aggression Restrained: Replicabilityof Brief Mindfulness Induction In Indonesian Sample

Jurnal Psikologi, 2019
Mindfulness practice is being promoted in Western countries as a means to improve one’s ability to restrain aggression under the “depleted” condition. The applicability of this framework in non-Western settings is yet to be determined. In this experiment
Cleoputri Al Yusainy, Wahyu Wicaksono
doaj   +1 more source

Effects of placebos vs. SMS reminders on homework compliance in cognitive behavioral therapy for depression: a randomized trial

Mediterranean Journal of Clinical Psychology, 2022
Background: Nonadherence to homework assignments is a frequent problem among patients with depression during cognitive-behavioral therapy (CBT). The present study investigated the effects of two additional treatment components of CBT: a placebo and SMS ...
Nina Jurinec, Anne Schienle
doaj   +1 more source

Fremanezumab for the Preventive Treatment of Chronic Migraine. [PDF]

, 2017
BACKGROUND: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investigated as a preventive treatment for migraine.
Aycardi, Ernesto, Bigal, Marcelo E., Blankenbiller, Tricia, Dodick, David W., Goadsby, Peter J., Grozinski-Wolff, Melissa, Ma, Yuju, Silberstein, Stephen D., Yang, Ronghua, Yeung, Paul P.   +9 more
core   +2 more sources

Placebo Responses and Placebo Effects in Functional Gastrointestinal Disorders

Frontiers in Psychiatry, 2020
Much has been written about the placebo effects in functional gastrointestinal disorders (FGD), especially in irritable bowel syndrome (IBS), driven by the early hypothesis that in randomized controlled trials (RCTs) of IBS, the placebo effect might be ...
Paul Enck, Sibylle Klosterhalfen
doaj   +1 more source