Results 21 to 30 of about 1,110,077 (212)

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes [PDF]

, 2016
Background The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown. Methods In this double-blind trial, we randomly assigned patients with type 2 diabetes
Bergenstal, RM, Brown-Frandsen, K, Buse, JB, Daniels, GH, Kristensen, P, LEADER Steering Committee on behalf of the LEADER Trial Investigators, Mann, JF, Marso, SP, Nauck, MA, Nissen, SE, Pocock, S, Poulter, NR, Ravn, LS, Steinberg, WM, Stockner, M, Zinman, B   +15 more
core   +1 more source

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]

, 2017
Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S., Hume, Heather A., John, Chandy C., Kasirye, Phillip, Lane, Adam, Latham, Teresa S., Ndugwa, Christopher M., Opoka, Robert O., Ware, Russell E.   +8 more
core   +2 more sources

Intralesional Bleomycin in Periungual Warts: A Prospective Randomised Controlled Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Periungual Warts (PW) are difficult to treat because of their challenging location, high recurrence rate and resistance to treatment. Bleomycin is a cheaper and readily available drug that has potential efficacy in treating warts, although ...
Kallolinee Samal, Nibedita Dixit, Srigopal Mohanty, Debjit Kar, Siddhartha Dash, Manoj Kumar Nayak   +5 more
doaj   +1 more source

Fremanezumab for the Preventive Treatment of Chronic Migraine. [PDF]

, 2017
BACKGROUND: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investigated as a preventive treatment for migraine.
Aycardi, Ernesto, Bigal, Marcelo E., Blankenbiller, Tricia, Dodick, David W., Goadsby, Peter J., Grozinski-Wolff, Melissa, Ma, Yuju, Silberstein, Stephen D., Yang, Ronghua, Yeung, Paul P.   +9 more
core   +2 more sources

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness [PDF]

, 2018
BACKGROUND: There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU). METHODS: In a randomized, double-blind, placebo-controlled trial, we assigned patients with acute ...
Bernard, G.R., Boehm, L.M., Bowton, D.L., Brummel, N.E., Carson, S.S., Chandrasekhar, R., Dittus, R.S., Douglas, I.S., Ely, E.W., Exline, M.C., Feinstein, D.J., Girard, T.D., Gong, M.N., Hite, R.D., Hough, C.L., Hughes, C.G., Hyzy, R.C., Jackson, J.C., Khan, B., Malhotra, A., Masica, A.L., Owens, R.L., Pandharipande, P.P., Patel, M.B., Pisani, M.A., Pun, B.T., Rock, P., Schmidt, G.A., Schweickert, W.D., Stollings, J.L., Strength, C., Thompson, J.L.   +31 more
core   +1 more source

Lack of Effects of the Presence of a Dog on Pain Perception in Healthy Participants—A Randomized Controlled Trial

Frontiers in Pain Research, 2021
Animal-assisted interventions (AAIs) have been shown to be effective in the treatment of pain. Studies suggest that relationships with animals can have comparable qualities to relationships with humans and that this enables animals to provide social ...
Cora Wagner, Jens Gaab, Cosima Locher, Cosima Locher, Cosima Locher, Karin Hediger, Karin Hediger, Karin Hediger, Karin Hediger   +8 more
doaj   +1 more source

Placebo Effect in the Treatment of Depression and Anxiety

Frontiers in Psychiatry, 2019
The aim of this review is to evaluate the placebo effect in the treatment of anxiety and depression. Antidepressants are supposed to work by fixing a chemical imbalance, specifically, a lack of serotonin or norepinephrine in the brain.
Irving Kirsch
doaj   +1 more source

Regulation with Placebo Effects [PDF]

, 2008
A growing scientific literature supports the existence of placebo effects from a wide range of health interventions and for a range of medical conditions.
Malani, Anup
core   +1 more source

Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. [PDF]

, 2014
Backgroundn-3 fatty acids inhibit neuronal excitability and reduce seizures in animal models. High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results.
DeGiorgio, Christopher M, Gornbein, Jeffrey, Harper, Ronald, Meymandi, Sheba, Miller, Patrick R, Schrader, Lara, Soss, Jason   +6 more
core   +1 more source

Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia

Frontiers in Psychiatry, 2021
The idea that maladaptive memories may be rendered susceptible to interference after reactivation raises the possibility of reactivating and neutralizing clinically-relevant emotional memories.
James W. B. Elsey, Merel Kindt
doaj   +1 more source