Results 291 to 300 of about 1,543,966 (410)
Tofacitinib for the Treatment of Juvenile Idiopathic Arthritis: Patient‐Reported Outcomes in a Phase III, Randomized, Double‐Blind, Placebo‐Controlled Withdrawal Trial
Arthritis &Rheumatology, Accepted Article.Objective
Juvenile idiopathic arthritis (JIA) is associated with impaired overall health‐related quality of life (HRQoL). We evaluated the impact of tofacitinib on patient‐reported outcomes (PROs) in patients with JIA. Methods
This was a post hoc analysis of a phase III, randomized, double‐blind, placebo‐controlled withdrawal trial (NCT02592434) in ...Hermine I. Brunner, Ekaterina Alexeeva, Marcia Bandeira, Ruy Carrasco, Jeffrey Chaitow, Peter Chiraseveenuprapund, Tracy V. Ting, Muferet Erguven, Beth Gottlieb, Sheila Knupp Oliveira, Pooja N. Patel, Seza Ozen, Claudia Saad Magalhaes, Inmaculada Calvo Penadés, David Gruben, Rebecca Germino, Holly B. Posner, Lori Stockert, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto, The Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG) +21 morewiley +1 more sourceIdentification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus
Arthritis &Rheumatology, Accepted Article.Objective
Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods
We identified an inhibitor of IFN‐I production from a chemical library.Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh +16 morewiley +1 more sourceEffects of Oveporexton, an Orexin Receptor 2-Selective Agonist, on Cognition in Narcolepsy Type 1: A Secondary Analysis of a Randomized Clinical Trial.
JAMA NeurolLammers GJ, Plazzi G, Mignot E, Pizza F, Dauvilliers Y, Barateau L, Maruff P, Scammell TE, Latzman RD, Naylor M, Olsson T, Stukalin E, Tanaka S, Volfson D, Khachadourian V, Harel BT. +15 moreeuropepmc +1 more sourceOral Lacticaseibacillus rhamnosus GG Exposure During Pregnancy and Effects on Maternal Inflammatory Response-A Blinded, Pilot Randomized, Placebo-Controlled Study. [PDF]
Am J Reprod ImmunolNordqvist M, Hallingström M, Nerén A, Bullarbo M, Kuusela P, Barman M, Thulin P, Sengpiel V, Jacobsson B. +8 moreeuropepmc +1 more sourceA placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.
New England Journal of Medicine, 2006 R. Belfort, S. Harrison, K. A. Brown, Celia Darland, J. Finch, Jean Hardies, B. Balas, A. Gastaldelli, F. Tio, Joseph P Pulcini, R. Berria, Jennie Z. Ma, S. Dwivedi, R. Havranek, C. Fincke, R. DeFronzo, G. Bannayan, S. Schenker, K. Cusi +18 moresemanticscholar +1 more sourceTrial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine
New England Journal of Medicine, 2017 S. Powers, C. Coffey, L. A. Chamberlin, D. Ecklund, Elizabeth A. Klingner, Jon W. Yankey, L. Korbee, L. Porter, A. Hershey +8 moresemanticscholar +1 more source