Results 331 to 340 of about 1,501,016 (387)

Population Pharmacokinetics and Exposure‐Response Analysis of First‐Line Osimertinib Plus Chemotherapy in Patients with EGFR‐Mutated Advanced NSCLC

Clinical Pharmacology &Therapeutics, EarlyView.
Osimertinib, a third‐generation, central nervous system‐active epidermal growth factor receptor‐tyrosine kinase inhibitor, potently and selectively inhibits epidermal growth factor receptor‐tyrosine kinase inhibitor sensitizing and T790M resistance mutations, with efficacy in epidermal growth factor receptor‐mutated non‐small cell lung cancer.
Jincheng Yang, Damilola Olabode, Aarti Sawant‐Basak, Richard Baldry, Karthick Vishwanathan, Srinivas Bachina, Alexandar Todd, Dana Ghiorghiu, Yuri Rukazenkov, Diansong Zhou, Azar Shahraz   +10 more
wiley   +1 more source

Aldosterone-targeted therapies: early implementation in resistant hypertension and chronic kidney disease. [PDF]

Eur Heart J
Kobayashi M, Pitt B, Ferreira JP, Rossignol P, Girerd N, Zannad F.   +5 more
europepmc   +1 more source

Hierarchical clustering of clinical and flow cytometry parameters is associated with deterioration in patients with community‐acquired pneumonia in the emergency department: A preliminary study

Cytometry Part B: Clinical Cytometry, EarlyView.
ABSTRACT Anticipating the evolution of septic patients with community‐acquired pneumonia (CAP) is challenging for front‐line physicians in the Emergency Department (ED). Prognosis depends mainly on early identification, antibiotics, organ support, but also immune status.
Thomas Lafon, Robin Jeannet, Thomas Daix, Guillaume Monneret, Jean Feuillard   +4 more
wiley   +1 more source

Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein-Losing Enteropathies: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. [PDF]

J Vet Intern Med
Jablonski SA, Shropshire SB, Watson VE, Manchester AC, Cridge H, Lennon EM, Tolbert MK.   +6 more
europepmc   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Endothelin Receptor Antagonists for the Treatment of Hypertension: Recent Data from Clinical Trials and Implementation Approach. [PDF]

Curr Cardiol Rep
Manickavasagar R, Krishnan A, Azzam O, Schlaich MP.   +3 more
europepmc   +1 more source

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

Drug Testing and Analysis, EarlyView.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel, Sylvia E. Escher, Emanuel Weiler, Anke Londenberg, Uwe Deppenmeier, Rhys Whomsley   +5 more
wiley   +1 more source

High-Frequency, At-Home Monitoring of Drug Safety and Tolerability in Clinical Trials: Results From Studies of Fluvoxamine for COVID-19 Treatment. [PDF]

Clin Transl Sci
Lenze EJ, Nykamp M, Miller JP, Stevens A, Schweiger J, Gettinger T, Yingling M, Zhang Y, Nicol GE, Zorumski CF, Reiersen AM.   +10 more
europepmc   +1 more source

Mechanisms of Change in Cognitive‐Behavioral Therapy for Adults With Binge‐Eating Disorder: A Dynamic Structural Equation Modeling Approach

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Cognitive‐behavioral therapy (CBT) is the most well‐established treatment for binge‐eating disorder (BED), but the mechanisms of change remain poorly understood. This study investigated in CBT for BED the effects of overvaluation of shape and weight and dietary restraint on subsequent objective binge‐eating episodes (OBEs). Method In
Ricarda Schmidt, Danielle Schewe, Stephan Herpertz, Stephan Zipfel, Brunna Tuschen‐Caffier, Hans‐Christoph Friederich, Andreas Mayr, Martina de Zwaan, Anja Hilbert   +8 more
wiley   +1 more source

Effectiveness of conditioning + open-label placebo for post-operative pain management in adolescent idiopathic scoliosis. [PDF]

Pain Manag
Furie KS, James K, Kaptchuk TJ, Diab M.
europepmc   +1 more source