Results 121 to 130 of about 935,031 (288)

Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain

Nature Communications
Drug treatments for pain often do not outperform placebo, and a better understanding of placebo mechanisms is needed to improve treatment development and clinical practice.
Rotem Botvinik-Nezer, Bogdan Petre, Marta Ceko, Martin A. Lindquist, Naomi P. Friedman, Tor D. Wager   +5 more
doaj   +1 more source

A virtual experimenter to increase standardization for the investigation of placebo effects

BMC Medical Research Methodology, 2016
Background Placebo effects are mediated by expectancy, which is highly influenced by psychosocial factors of a treatment context. These factors are difficult to standardize.
Bjoern Horing, Nathan D. Newsome, Paul Enck, Sabarish V. Babu, Eric R. Muth   +4 more
doaj   +1 more source

The role of cognitive reappraisal in placebo analgesia: an fMRI study

Social Cognitive and Affective Neuroscience, 2017
Placebo analgesia (PA) depends crucially on the prefrontal cortex (PFC), which is assumed to be responsible for initiating the analgesic response. Surprisingly little research has focused on the psychological mechanisms mediated by the PFC and underlying
M. van der Meulen, S. Kamping, F. Anton
semanticscholar   +1 more source

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Exploration of High and Low Frequency Options for Subperception Spinal Cord Stimulation Using Neural Dosing Parameter Relationships: The HALO Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Subperception spinal cord stimulation (SCS) is described mostly utilizing waveforms that require high energy. However, the necessity of these waveforms for effective subperception has not been established. We aimed to explore whether effective subperception pain relief can be achieved using frequencies below 1 kHz.
José Paz‐Solís, Simon Thomson, Roshini Jain, Lilly Chen, Ismael Huertas, Que Doan   +5 more
wiley   +1 more source

Training on the quadriceps of individuals with rheumatoid arthritis: A systematic review and meta‐analysis

Rheumatology &Autoimmunity, EarlyView.
Physical training significantly improves quadriceps strength in patients with rheumatoid arthritis. No serious adverse events were reported. Abstract Background Rheumatoid arthritis is a chronic, systemic disease in which patients can benefit from physical exercise.
Mariana Laís Boaretto, Diego Francis Saraiva Rodriguez, Dartel Ferrari de Lima, Cristiane Buzanello Donin, Alberito Rodrigo de Carvalho, Márcia Rosângela Buzanello, Gladson Ricardo Flor Bertolini   +6 more
wiley   +1 more source

Safety and Efficacy of 10 kHz Spinal Cord Stimulation for the Treatment of Refractory Chronic Migraine: A Prospective Long‐Term Open‐Label Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Background Refractory chronic migraine (rCM) is a highly disabling condition for which novel safe and effective treatments are needed. Safety and long‐term efficacy of paresthesia‐free high cervical 10 kHz spinal cord stimulation (SCS) were here prospectively evaluated for the treatment of rCM.
Adnan Al‐Kaisy, Stefano Palmisani, Roy Carganillo, Samuel Wesley, David Pang, Anand Rotte, Angela Santos, Giorgio Lambru   +7 more
wiley   +1 more source

A prefrontal non-opioid mechanism in placebo analgesia [PDF]

, 2010
ehavioral studies have suggested that placebo analgesia is partly mediated by the endogenous opioid system. Expanding on these results we have shown that the opioid-receptor-rich rostral anterior cingulate cortex (rACC) is activated in both placebo and ...
Kalso, E,, Kalso, E., Ingvar, M., Ingvar, M,, Fransson, P., Fransson, P,, Petrovic, P,, Petrovic, P., Andersson, J., Petersson, KM, Andersson, J, Petersson, K., Karl Magnus Petersson, Martin Ingvar, Predrag Petrovic, Eija Kalso, Peter Fransson, Jesper Andersson   +17 more
core   +1 more source

Effect of transcutaneous electrical nerve stimulation on physical activity and pain evaluation in osteoarthritic dogs

Veterinary Record, EarlyView.
Abstract Background Osteoarthritis (OA) causes chronic pain and reduces welfare in dogs. Standard treatments may be inadequate or associated with adverse effects, prompting investigation of alternative therapies. Transcutaneous electrical nerve stimulation (TENS) is a non‐pharmacological pain management method, but evidence for its efficacy in canine ...
Anja Pedersen, Johanna Penell, Emil Olsen, Heli Hyytiäinen, Franck Forterre, Anna Bergh   +5 more
wiley   +1 more source

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source