Results 211 to 220 of about 935,031 (288)

Update on Sedation for Upper Gastrointestinal Endoscopy in Japan: Current Evidence on Remimazolam

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Sedation is an essential component of upper gastrointestinal endoscopy because it reduces patient discomfort and anxiety while improving patient acceptance and procedural quality. In Japan, benzodiazepines such as midazolam and opioid analgesics have long been widely used in routine clinical practice; however, many of these agents historically
Ryoji Ichijima, Masahiro Toyama, Taiki Shishido, Yuki Koyo, Takehiro Yoshii, Reona Kawamura, Tsubasa Ishikawa, Yasuhiko Mizuguchi, Naoya Toyoshima, Hiroyuki Takamaru, Masayoshi Yamada, Masau Sekiguchi, Seiichiro Abe, Yutaka Saito   +13 more
wiley   +1 more source

Efficacy and safety of ketamine for post‐traumatic stress disorder: A systematic review with narrative synthesis and consideration of military and veteran populations

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Post‐traumatic stress disorder (PTSD) is a debilitating disorder with limited pharmaceutical treatment options. Ketamine, a noncompetitive N‐methyl‐d‐aspartate (NMDA) receptor antagonist with rapid‐onset effects, has emerged as a potential treatment, particularly for patients who do not respond to first‐line therapies.
Mary Ivasyutyn, Saajan Bhakta
wiley   +1 more source

Placebo analgesia induced by verbal suggestion in the context of experimentally induced fear and anxiety. [PDF]

PLoS One, 2019
Świder K, Bąbel P, Wronka E, van Rijn CM, Oosterman JM.   +4 more
europepmc   +1 more source

Therapeutic Strategies for a Narrative Review With Emphasis on Intravesical, Procedural and Regenerative Approaches Bladder Pain Syndrome

Trends in Urology &Men's Health, Volume 17, Issue 6, December 2026.
ABSTRACT Bladder pain syndrome (BPS) is a chronic, heterogeneous condition impair patients' quality of life. expanding body of clinical evidence clinical decision‐making is by variability in patient phenotypes, endpoints, and follow‐up. significantlyingWhilst there is anin relation to potential treatment options, often hindered study inconsistencies ...
Zhila Sheikhi, Bagher Soleimani, Mohammad Aslzare, Malihe Aghasizadeh, Parisa Qayenipour   +4 more
wiley   +1 more source

Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11946-11954, December 2026.
ABSTRACT Aims Crisugabalin (HSK16149), a selective γ‐aminobutyric acid (GABA) analog, has shown preliminary efficacy in controlling diabetic peripheral neuropathic pain (DPNP), but efficacy in patients with inadequate response to prior pregabalin treatment remains unknown. Materials and Methods This multicentre randomized controlled trial was conducted
Yaming Li, Fang Zhang, Wei Liu, Xiuhai Su, Bin Zhou, Na Xu, Junjie Shang, Chen Fang, Liujun Fu, Fangqiong Li, Chao Zheng, Jinyou Duan   +11 more
wiley   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, Volume 78, Issue 11, Page 1781-1790, November 2026.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, Volume 101, Issue 11, Page 2799-2811, November 2026.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

Placebo Analgesia in Rodents: Current and Future Research. [PDF]

Int Rev Neurobiol, 2018
Keller A, Akintola T, Colloca L.
europepmc   +1 more source

The Role of Social and Interpersonal Factors in Placebo Analgesia. [PDF]

Int Rev Neurobiol, 2018
Necka EA, Atlas LY.
europepmc   +1 more source

Pain‐Related Outcome Domains and Measures in Randomized Controlled Trials of Treatment for Acute Abdominal Pain: A Systematic Review

European Journal of Pain, Volume 30, Issue 10, November 2026.
ABSTRACT Background and Objectives Acute abdominal pain frequently presents to emergency departments, yet outcome domains in randomized controlled trials (RCTs) remain poorly characterized. This review identified pain‐related domains and outcome measures used in RCTs on acute abdominal pain.
Louise Kuhlmann, Cecilie Siggaard Knoph, Søren Schou Olesen, Nejo Joseph, John Windsor, Asbjørn M. Drewes, Sanjay Pandanaboyana, Esther Pogatzki‐Zahn   +7 more
wiley   +1 more source