Arthritis &Rheumatology, EarlyView.Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera +14 more
wiley +1 more source
Consideration in Randomized Placebo-Controlled Trial on Neck Pain to Avoid the Placebo Effect in Analgesic Action. [PDF]
Front Pharmacol, 2022 Sun YL +11 more
europepmc +1 more source
Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy [PDF]
, 2000 Tim Ubhi
openalex +1 more source
Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis
Arthritis &Rheumatology, Accepted Article.Objectives Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The Phase III MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E Wechsler +34 more
wiley +1 more source
Vascular co‐option and vasculogenic mimicry mediate resistance to antiangiogenic strategies
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background The concept that all the tumors need the formation of new vessels to grow inspired the hypothesis that inhibition of angiogenesis would have led to “cure” cancer. The expectancy that this type of therapy would have avoided the insurgence of resistance was based on the concept that targeting normal vessels, instead of the cancer ...
Francesco Pezzella, Domenico Ribatti
wiley +1 more source
Myths and Truths about Placebo Effect in Rehabilitation for Musculoskeletal Pain. [PDF]
Adv Ther, 2021 Iolascon G, Moretti A.
europepmc +1 more source
The Effect of Low Dose Micronized 17β-Estradiol on Bone Turnover, Sex Hormone Levels, and Side Effects in Older Women: A Randomized, Double Blind, Placebo-Controlled Study1 [PDF]
, 2000 Karen M. Prestwood +3 more
openalex +1 more source
Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 94-106, January 2023., 2023 Abstract Deutetrabenazine (Austedo) is indicated in adults for chorea associated with Huntington disease and tardive dyskinesia. Escalating deutetrabenazine doses were administered to healthy volunteers who were cytochrome P450 2D6 extensive/intermediate metabolizers (EMs) or poor metabolizers (PMs) to determine pharmacokinetic exposure of parent drug ...
Frank Schneider +7 more
wiley +1 more source
[What can psychotherapy learn from the placebo effect?] [PDF]
Psychotherapeut (Berl), 2022 Rief W.
europepmc +1 more source
The Placebo Effect and White Coat Effect in Isolated Systolic Hypertension and Systo-diastolic hypertension [PDF]
, 2000 Gregory Y. H. Lip Dirk C. Felmeden
openalex +1 more source