Results 281 to 290 of about 14,611,928 (419)

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle   +13 more
wiley   +1 more source

Does ischemic preconditioning really improve performance or it is just a placebo effect? [PDF]

open access: yesPLoS One, 2021
de Souza HLR   +4 more
europepmc   +1 more source

Investigation of a broad‐spectrum micronutrient formulation as a possible precipitant of pharmacokinetic micronutrient–drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew   +7 more
wiley   +1 more source

Placebo Effect of Caffeine on Substrate Oxidation during Exercise. [PDF]

open access: yesNutrients, 2021
Gutiérrez-Hellín J   +7 more
europepmc   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia   +4 more
wiley   +1 more source

Placebo Effect of Caffeine on Physiological Parameters and Physical Performance. [PDF]

open access: yesNutrients
Ortiz-Sánchez D   +4 more
europepmc   +1 more source

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