Results 301 to 310 of about 14,611,928 (419)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

100,000 lumens to treat seasonal affective disorder: A proof of concept RCT of Bright, whole‐ROom, All‐Day (BROAD) light therapy

Depression and Anxiety, Volume 39, Issue 12, Page 760-769, December 2022., 2022
Abstract Background Seasonal affective disorder (SAD) is common and debilitating. The standard of care includes light therapy provided by a light box; however, this treatment is restrictive and only moderately effective. Advances in LED technology enable lighting solutions that emit vastly more light than traditional light boxes.
Julia F. Sandkühler, Sarah Brochhagen, Paul Rohde, Rosa C. Muscheidt, Teja W. Grömer, Helge Müller, Jan M. Brauner   +6 more
wiley   +1 more source

Comparison of oral zinc supplement and placebo effect in improving the T-cells regeneration in patients undergoing autologous hematopoietic stem cell transplantation: Clinical trial study. [PDF]

Medicine (Baltimore)
Nikoonezhad M, Zavaran Hosseini A, Hajifathali A, Parkhideh S, Shadnoush M, Shakiba Y, Zahedi H.   +6 more
europepmc   +1 more source

Randomized placebo-controlled trial to assess the effect of remifentanil and propofol on bispectral index and sedation

, 2000
Andrew Strachan, N. D. Edwards
openalex   +1 more source

Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled [PDF]

, 2001
Olaf Müller
openalex   +1 more source

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

Placebo Effect in the Treatment of Patellar Tendinopathy and Its Influencing Factors: Systematic Review With Meta-analysis and Meta Regression of Randomized Controlled Trials. [PDF]

Orthop J Sports Med
Previtali D, Albanese J, Romandini I, Merli G, Taraballi F, Filardo G.   +5 more
europepmc   +1 more source

From the New Diagnostic Criteria to COVID-19 Pandemic Passing Through the Placebo Effect. What Have We Learned in the Management of Pediatric Migrane Over the Past 5 Years? [PDF]

Front Neurol, 2022
Papetti L, Tarantino S, Ursitti F, Moavero R, Proietti MC, Sforza G, Monte G, Ferilli MAN, Balestri M, Vigevano F, Valeriani M.   +10 more
europepmc   +1 more source

Mechanisms of the placebo effect in pain and psychiatric disorders

The Pharmacogenomics Journal, 2016
RD Holmes, AK Tiwari, JL Kennedy
semanticscholar   +1 more source

Placebo effect of carbohydrate feedings during a 40-km cycling time trial

, 2000
V. R. Clark, Will G. Hopkins, John A. Hawley, Louise M. Burke   +3 more
openalex   +1 more source