Results 91 to 100 of about 114,155 (256)
Placebo Response is Driven by UCS Revaluation: Evidence, Neurophysiological Consequences and a Quantitative Model [PDF]
arXiv, 2016 Despite growing scientific interest in the placebo effect and increasing understanding of neurobiological mechanisms, theoretical modeling of the placebo response remains poorly developed. The most extensively accepted theories are expectation and conditioning, involving both conscious and unconscious information processing.
arxiv
Impure placebo as an unsound concept and other problems in the paper by Howick et al. : [Comment] [PDF]
, 2013 Howick et al. have reported the findings of a survey that addressed the use of placebos among primary care practitioners in the United Kingdom. They adopted methodology similar to that used in previous studies performed in other countries; however, the ...
Hemilä, Harri +2 more
core
Diabetology & Metabolic Syndrome, 2020 Background Prediabetes can predispose the individual to type 2 diabetes in the long-term. The present study was conducted to determine the effectiveness of vitamin D and omega-3 co-supplementation on glycemic control and serum lipid profiles in women of ...
Masoumeh Rajabi-Naeeni +3 more
doaj +1 more source
Using instrumental variables to disentangle treatment and placebo effects in blinded and unblinded randomized clinical trials influenced by unmeasured confounders [PDF]
arXiv, 2016 Clinical trials traditionally employ blinding as a design mechanism to reduce the influence of placebo effects. In practice, however, it can be difficult or impossible to blind study participants and unblinded trials are common in medical research. Here we show how instrumental variables can be used to quantify and disentangle treatment and placebo ...
arxiv
Placebo design in WHO-registered trials of Chinese herbal medicine need improvements
BMC Complementary and Alternative Medicine, 2019 Background Physical identical and pharmacological inert are the basic requirements for placebo design, which are essential in clinical trials to evaluate the efficacy of an intervention.
Xuan Zhang +5 more
doaj +1 more source
Problematic placebos in physical therapy trials [PDF]
, 2016 The placebo controlled, randomised controlled trial is widely recognised as the gold standard design for providing evidence in health care. Yet controversies surrounding placebos persist, which include issues regarding ethics, legality, mechanisms, and ...
Beecher +28 more
core +2 more sources
Journal of Acupuncture ResearchControl group selection in clinical trials is challenging, especially in acupuncture studies. A PubMed literature review of control groups in breast cancer acupuncture studies was performed and identified 67 studies for analysis.
Molly Siegel +5 more
doaj +1 more source
Placebo: Feeling Better, Getting Better, and the Problems of Mind and Body [PDF]
, 2008 Over its history, medicine has vacillated between acknowledging placebo effects as important and trying to overcome them. Placebos are controversial, in part, because they appear to challenge a biocentric view of the scientific basis of medical practice.
Kihlstrom, John F.
core +1 more source
BMJ Open, 2019 Introduction Physicians and other prescribing clinicians use opioids as the primary method of pain management after traumatic injury, despite growing recognition of the major risks associated with usage for chronic pain.
Thomas Scalea +13 more
doaj +1 more source
Point and interval estimation of the target dose using weighted regression modelling [PDF]
arXiv, 2020 In a Phase II dose-finding study with a placebo control, a new drug with several dose levels is compared with a placebo to test for the effectiveness of the new drug. The main focus of such studies often lies in the characterization of the dose-response relationship followed by the estimation of a target dose that leads to a clinically relevant effect ...
arxiv