Results 101 to 110 of about 484,364 (380)

Rehabilitation interventions for foot drop in neuromuscular disease [PDF]

, 2007
"Foot drop" or "Floppy foot drop" is the term commonly used to describe weakness or contracture of the muscles around the ankle joint.
Disler, Peter B., Sackley, Catherine, Turner-Stokes, Lynne, Wade, Derick T.   +3 more
core   +1 more source

Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome

PLoS ONE, 2010
Background Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception. We tested whether open-label placebo (non-deceptive and non-concealed administration)
T. Kaptchuk, T. Kaptchuk, Elizabeth A. Friedlander, J. Kelley, J. Kelley, M. Sanchez, E. Kokkotou, Joyce P. Singer, Magda Kowalczykowski, F. Miller, I. Kirsch, A. Lembo   +11 more
semanticscholar   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Should desperate volunteers be included in randomised controlled trials? [PDF]

, 2005
Randomised controlled trials (RCTs) sometimes recruit participants who are desperate to receive the experimental treatment. Some claim this practice is unethical for at least three reasons. The first is that the notion of equipoise, which is often used
Allmark, P. J., Mason, S.
core   +2 more sources

Steps to Strengthen Ethics in Organizations: Research Findings, Ethics Placebos, and What Works

Journal of Trauma & Dissociation, 2015
Research shows that many organizations overlook needs and opportunities to strengthen ethics. Barriers can make it hard to see the need for stronger ethics and even harder to take effective action. These barriers include the organization’s misleading use
K. Pope
semanticscholar   +1 more source

Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei, Qian Liu, Guoxin Liu, Manjie Zhang, Jiaxin Fang, Xuting He, Xueqi He, Zhengwei Qin, Ronghua Liu, Chuang Liu, Hongyu Ji, Yuechao Dong, Ye Yuan, Baofeng Yang, Weijie Du   +14 more
wiley   +1 more source

Effects of placebos without deception compared with no treatment: protocol for a systematic review and meta-analysis

BMJ Open, 2015
Introduction Placebos have long provided a robust control for evaluating active pharmacological preparations, but frequently demonstrate a variable therapeutic effect when delivered in double-blinded placebo-controlled trials.
G. Petkovic, J. Charlesworth, John Kelley, F. Miller, N. Roberts, J. Howick   +5 more
semanticscholar   +1 more source

Do antidepressants cure or create abnormal brain states? [PDF]

, 2006
Moncrieff and Cohen argue that psychotropic drugs create abnormal states that may co-incidentally relieve symptoms of mental ...
Beasley, Beasley, Bourin, Breggin, Cohen, David Cohen, Delgado, Deptula, Dewa, Drevets, Dumont, Emrich, Fisher, Furlan, Goldberg, Harmer, Harmer, Herrmann, Hyman, Imlah, Joanna Moncrieff, Kennedy, Kirsch, Knegtering, Lacasse, Leo, Lowther, Malhi, Matsubara, Mayers, Meyer, Moncrieff, Moncrieff, Moncrieff, Moncrieff, Murphy, Niklson, Parsey, Patten, Pilgrim, Ramaekers, Ramaekers, Raptopoulos, Reivich, Rickels, Robbe, Robertson, Robinson, Rush, Sargent, Schildkraut, Stockmeier, Tranter, Tuma, Van Putten, Wingen   +55 more
core   +3 more sources

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Use of placebo interventions among Swiss primary care providers

BMC Health Services Research, 2009
Background Placebo interventions can have meaningful effects for patients. However, little is known about the circumstances of their use in clinical practice.
Rosemann Thomas, Gnädinger Markus, Fässler Margrit, Biller-Andorno Nikola   +3 more
doaj   +1 more source