Results 141 to 150 of about 488,286 (382)
Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé +5 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Emerging evidence suggests a possible link between rhinosinusitis and systemic rheumatic diseases; however, no meta‐analysis has comprehensively examined this association to date. We aimed to investigate if patients with rhinosinusitis have a predisposition to unmasking rheumatic diseases compared to individuals without ...
Arshbir Aulakh +5 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Vitamin D, traditionally known to promote calcium and bone health, is being explored for its role in cancer prevention and treatment through its influence on cell proliferation, differentiation, apoptosis, and immune response. The vitamin D receptor (VDR) regulates gene expression and interacts with key signaling pathways such as Wnt/β‐catenin, MAPK ...
D. Prasanth +10 more
wiley +1 more source
Estrogen treatment for cancer of the prostate.Early results with 3 doses of diethylstilbestrol and placebo [PDF]
, 1970 John C. Bailar, David P. Byar
openalex +1 more source
Annals of Neurology, EarlyView.Objective The efficacy and safety of intra‐arterial thrombolysis (IAT) as an adjunct to endovascular thrombectomy (EVT) in large vessel occlusion strokes (LVOS) remain uncertain, with recent randomized controlled trials (RCTs) yielding conflicting results.
Mohamed F. Doheim +20 more
wiley +1 more source
New Evidence on Financial Incentives and the Timing of Retirement [PDF]
We investigate the responsiveness of individual retirement decisions to changes in financial incentives. The causal effect is identified based on the natural experiment generated by an institutional reform.
Barbara Hanel, Regina T. Riphahn
core
Maintenance digoxin after an episode of heart failure: placebo-controlled trial in outpatients. [PDF]
, 1977 Sylvia M. Dobbs +2 more
openalex +1 more source
Annals of Neurology, EarlyView.Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke +36 more
wiley +1 more source
Placebos in the Treatment of Rheumatoid Arthritis and other Rheumatic Conditions
, 1957 Eugene F. Traut, E Passarelli
openalex +1 more source
Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas
Annals of Neurology, EarlyView.Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek +7 more
wiley +1 more source