Results 181 to 190 of about 495,708 (385)

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Efficacy of the Combination of Pinaverium Bromide 100 mg Plus Simethicone 300 mg in Abdominal Pain and Bloating in Irritable Bowel Syndrome: A Randomized, Placebo-controlled Trial

, 2019
Max J. Schmulson, Jazmin Chiu-Ugalde, A. Sáez-Ríos, Aurelio López‐Colombo, Gualberto Mateos-Pérez, J.M. Remes-Troche, Sergio Sobrino-Cossío, Julio César Soto-Pérez, José Luis Tamayo de la Cuesta, Óscar Teramoto-Matsubara, Juan Carlos López-Alvarenga   +10 more
openalex   +1 more source

Oral domperidone versus placebo for enhancing exclusive breastfeeding among post-lower segment cesarean section mothers – a double-blind randomized controlled trial

, 2023
Arumugom Archana, B. Adhisivam, Latha Chaturvedula, Sadhana Subramanian   +3 more
openalex   +1 more source

A Phase 2b, Randomised, Double-blind, Placebo-controlled, Parallel-arm, Multicenter Study Evaluating the Safety and Efficacy of Tesnatilimab in Patients with Moderately to Severely Active Crohn’s Disease [PDF]

, 2023
Matthieu Allez, Bruce E. Sands, Brian G. Feagan, Geert D’Haens, Gert De Hertogh, Charles Randall, Bin Zou, Jewel Johanns, Christopher O’Brien, Mark Curran, Rory Rebuck, Mei‐Lun Wang, Nina Chi-Sabins, Thomas Baker, Taku Kobayashi   +14 more
openalex   +1 more source

Distortion in the Communication of Nonsignificant Primary Outcomes: The Spin Strategy in Multiple Sclerosis Trials

Annals of Neurology, EarlyView.
Objective Spin refers to reporting strategies that highlight the benefits of an experimental treatment or divert attention from nonsignificant primary outcomes. To assess spin in randomized clinic trials (RCTs) on pharmaceutical efficacy in multiple sclerosis (MS) and explore associated factors.
Marta Mascareñas‐García, Alejandro Rivero‐de‐Aguilar, Cristina Candal‐Pedreira, Guadalupe García, Carla Guerra‐Tort, Lucía Martín‐Gisbert, Julia Rey‐Brandariz, Mónica Pérez‐Ríos Ríos, Beatriz Casal‐Acción, María Isolina Santiago‐Pérez, Leonor Varela‐Lema   +10 more
wiley   +1 more source

Lactobacillus paragasseri SBT2055 Activates Plasmacytoid Dendritic Cells and Improves Subjective Symptoms of Common Cold in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Comparative Trial [PDF]

, 2023
Eiji Kobatake, Yoshitaka Iwama, Toshinobu Arai, Yuki Tsukisaka, Toshihide Kabuki   +4 more
openalex   +1 more source

Placebo or no placebo? [PDF]

Nature, 1990
openaire   +1 more source

Intranasal Seletracetam in a Patient with Reading Epilepsy: First‐in‐Human Use to Prevent Reflex Seizures

Annals of Neurology, EarlyView.
We report the first human use of intranasal seletracetam (SEL) to prevent reflex seizures. A patient with epilepsy with reading‐induced seizures on levetiracetam (3,000 mg/day) continued to experience reading‐induced focal seizures with preserved consciousness.
Matthias J. Koepp, Kai‐Nicolas Poppert, Thomas Felder, Aljoscha Thomschewski, Sandra Lafenthaler, Pavel Klein, Alexander Rotenberg, Wolfgang Löscher, Chris Rundfeldt, Eugen Trinka   +9 more
wiley   +1 more source

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

Annals of Neurology, EarlyView.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains a significant challenge.
Yue Qiao, Adrien Ter Schiphorst, Yi Xu, Jean‐Claude Baron, Wenbo Zhao   +4 more
wiley   +1 more source

Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial [PDF]

Mahsa Rezaei, Mitra Soltani, Elham Alipoor, Seyed Mahdi Rezayat, Ali Vasheghani‐Farahani, Mehdi Yaseri, Ata Firouzi, Mohammad Javad Hosseinzadeh‐Attar   +7 more
openalex   +1 more source