Results 181 to 190 of about 116,751 (358)

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo, Ajay Madan, Christine T. Ferrara‐Cook, Deepak Dalvie, Lance Goulet, R. Scott Struthers, Alan S. Krasner   +6 more
wiley   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

The Illusion of Performance: The Effect of Phantom Display Refresh Rates on User Expectations and Reaction Times [PDF]

arXiv
User expectations impact the evaluation of new interactive systems. Increased expectations may enhance the perceived effectiveness of interfaces in user studies, similar to a placebo effect observed in medical studies. To showcase the placebo effect, we conducted a user study with 18 participants who performed a target selection reaction time test with
arxiv  

The effect of Barberry Juice supplement on Prostaglandin E2 level caused by intense aerobic activity in active young girls

مجله دانشگاه علوم پزشکی بیرجند, 2017
Background and Aim: Intense exercise can cause damages caused by oxidative stress and inflammation and, as a result, reduce exercise performance. The present study aimed at determining the effect of barberry juice supplement on the inflammation caused by
Babak Hooshmand Moghadam, Mohammad Reza Kordi, Sahabeh Mahdian   +2 more
doaj  

Weiße Kittel, Schwarze Magie : Placebo nutzen, Nocebo kennen [PDF]

, 2013
Rezension zu: Magnus Heier, Andreas S. Ziegler: Weiße Kittel – Schwarze Magie. Placebos und Nocebos als Blendwerk der Medizin.
Hardy, Anne
core  

PETHIDINE COMPARED WITH PETHIDINE PLUS LEVALLORPHAN AND WITH A PLACEBO

, 1965
P J Tomlin
openalex   +1 more source

Do placebos alter sleep? [PDF]

, 1976
K Adám, L. Adamson, V Březinová, Isabelle P. Oswald   +3 more
openalex   +1 more source

The importance of considering the gout flare: let's learn to walk and chew gum at the same time in gout clinical trial design

Arthritis &Rheumatology, Accepted Article.
Lisa K Stamp, Martin A Kennedy, Nicola Dalbeth   +2 more
wiley   +1 more source

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

An Attempt to Establish a Placebo Effect in Rats With Psychopharmacological Agents.

, 1963
Charles Black
openalex   +2 more sources