Results 231 to 240 of about 484,364 (380)

On blaming the placebo [PDF]

open access: yesArthritis & Rheumatism, 1991
Curtis J. Henke, Wallace V. Epstein
openaire   +3 more sources

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia‐inducible factor‐2α inhibitor, in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi   +11 more
wiley   +1 more source

Medication adherence during the run‐in phase of clinical trials: A systematic review of methodological and reporting rigour

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Trial run‐in phases are sometimes used to select adherent participants as a strategy to enrich trials, but the methods employed lack clear regulatory guidance and there are concerns about the transparency of reporting. This review aims to characterize the methods used for adherence measurement and public reporting of run‐in studies.
Non Davies   +3 more
wiley   +1 more source

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