Results 61 to 70 of about 22,441 (303)

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

Placebos in Healthcare: A Behavioral Study on How Treatment Responsiveness Affects Therapy Decisions in a Simulated Patient–Physician Interaction

Clinics and Practice
Background and Purpose: Treatment choice during clinical practice is crucial to best help each patient. One of the physicians’ main goals is choosing a personalized effective treatment, but it also represents a challenging issue.
Alessandro Piedimonte, Valeria Volpino, Francesco Campaci, Francesca Borghesi, Giulia Guerra, Elisa Carlino   +5 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Placebo Effects on the Enjoyment of Physical Activity and Performance among Kindergarten Children: A Randomized Controlled Trial

European Journal of Investigation in Health, Psychology and Education
Studies with adults and school children have shown that placebos can enhance motivation and performance in physical activities. This study aimed to investigate whether similar effects are present in kindergarten-aged children. A total of 101 children (58
Marlies Stopper, Albert Wabnegger, Anne Schienle   +2 more
doaj   +1 more source

Developing a placebo-controlled trial in surgery: issues of design, acceptability and feasibility [PDF]

, 2011
<p>Background: Surgical placebos are controversial. This in-depth study explored the design, acceptability, and feasibility issues relevant to designing a surgical placebo-controlled trial for the evaluation of the clinical and cost effectiveness ...
Campbell, MK, McDonald, AM, Skea, Z.C, Sutherland, AG, ZC Skea, Norrie, J.D, Campbell, M.K., Cuthbertson BH, Bridgman, S., McDonald, A.M, BH Cuthbertson, AM McDonald, McDonald AM, RV Carlson, McDonald, A.M., Skea, Z.C., S Bridgman, Carlson, R V, Entwistle, V.A, Sutherland, A.G, Cuthbertson, B H, JD Norrie, Norrie, J. D., Campbell, M K, Cuthbertson, B. H., Skea, Z. C., Skea, ZC, Carlson, RV, Sutherland AG, null null, MK Campbell, Carlson, R.V., Entwistle, Vikki, McDonald, A M, Norrie, JD, Skea ZC, VA Entwistle, Carlson, R.V, Skea, Z C, AG Sutherland, Entwistle, V A, Carlson RV, Entwistle, V.A., Norrie, J D, Sutherland, A.G., Bridgman, S, Norrie, J.D., Entwistle, V. A., Sutherland, A G, Campbell, M.K, Entwistle VA, McDonald, A. M., KORAL study group, Cuthbertson, B.H., Sutherland, A. G., Cuthbertson, B.H, Campbell MK, Campbell, M. K., Entwistle, VA, Cuthbertson, BH, Bridgman S, Carlson, R. V., Norrie JD   +62 more
core   +2 more sources

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Placebos in clinical practice: an ethical overview

, 2014
The use of placebos in clinical settings raises a host of important ethical issues. On the one hand, ethical guidelines tend to categorically prohibit the clinical use of placebos because they require deception.
Annoni M, Miller F G
core   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

Comparison of ondansetron, metoclopramid, hyoscine and dexamethasone for prevention of post-operative vomiting in cataract surgery

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
Introduction: Postoperative nausea and vomiting (PONV) complicates the lives of patients. Most of antiemetic drugs used prevent PONV after surgery, but they have undesirable adverse effects such as excessive sedation, hypotension, dysphoria and ...
Masoud Ghaneei, Reza sahraei
doaj