Frontiers in Pharmacology, 2014 Synthesis of thyroid hormones, thyroxine (T4) and tri-iodothyronine (T3), in the human fetus starts from 17-19th weeks of gestation. Despite the majority of normal pregnant women reaching adequate levels of circulating thyroid hormones, in some cases ...
Enrique eGuzmán-Gutiérrez +6 more
doaj +1 more source
Time domain computational modelling of 1D arterial networks in monochorionic placentas [PDF]
, 2003 Published ...
Cockburn +13 more
core +1 more source
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Reproductive Biology and Endocrinology, 2009 Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg +7 more
doaj +1 more source
Use of sildenafil citrate in cases of intrauterine growth restriction (IUGR); a prospective trial
Taiwanese Journal of Obstetrics & Gynecology, 2018 Objective: Intrauterine growth restriction (IUGR) is one of the most serious complications of pregnancy. Up to date, there is no evidence of achieving antenatal treatment of IUGR with abnormal placentation.
Mohammed Maged +3 more
doaj +1 more source
Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects. [PDF]
PLoS ONE, 2013 Lipopolysaccharide (LPS) in high doses inhibits placental multidrug resistance P-glycoprotein (P-gp--Abcb1a/b) and breast cancer resistance protein (BCRP--Abcg2).
Enrrico Bloise +6 more
doaj +1 more source
Hepcidin and iron homeostasis during pregnancy. [PDF]
, 2014 Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke +4 more
core +1 more source
Maternal Cardiovascular Impairment in Pregnancies Complicated by Severe Fetal Growth Restriction [PDF]
, 2012 —Fetal growth restriction and preeclampsia are both conditions of placental etiology and associated to increased risk for the long-term development of cardiovascular disease in the mother. At presentation, preeclampsia is associated with maternal global
Liberati, M +3 more
core +1 more source
Circulating soluble endoglin and placental abruption [PDF]
Prenatal Diagnosis, 2008 AbstractObjectiveOur objective was to investigate whether serum concentrations of a novel anti‐angiogenic factor, soluble endoglin (sEng), could predict placental abruption.MethodsIn a nested case–control study of nulliparous pregnancies, we examined levels of sEng in serum collected prospectively from 31 women who later developed placental abruption ...
Caroline, Signore +6 more
openaire +2 more sources
Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]
, 2007 Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD +6 more
core +1 more source
A computational model of the fetal circulation to quantify blood redistribution in intrauterine growth restriction. [PDF]
PLoS Computational Biology, 2014 Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood flow redistribution in order to maintain delivery of oxygenated blood to the brain.
Patricia Garcia-Canadilla +7 more
doaj +1 more source