Results 21 to 30 of about 37,462 (251)
Frontiers in Pharmacology, 2014 Synthesis of thyroid hormones, thyroxine (T4) and tri-iodothyronine (T3), in the human fetus starts from 17-19th weeks of gestation. Despite the majority of normal pregnant women reaching adequate levels of circulating thyroid hormones, in some cases ...
Enrique eGuzmán-Gutiérrez +6 more
doaj +1 more source
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Reproductive Biology and Endocrinology, 2009 Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg +7 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source
Use of sildenafil citrate in cases of intrauterine growth restriction (IUGR); a prospective trial
Taiwanese Journal of Obstetrics & Gynecology, 2018 Objective: Intrauterine growth restriction (IUGR) is one of the most serious complications of pregnancy. Up to date, there is no evidence of achieving antenatal treatment of IUGR with abnormal placentation.
Mohammed Maged +3 more
doaj +1 more source
Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects. [PDF]
PLoS ONE, 2013 Lipopolysaccharide (LPS) in high doses inhibits placental multidrug resistance P-glycoprotein (P-gp--Abcb1a/b) and breast cancer resistance protein (BCRP--Abcg2).
Enrrico Bloise +6 more
doaj +1 more source
A computational model of the fetal circulation to quantify blood redistribution in intrauterine growth restriction. [PDF]
PLoS Computational Biology, 2014 Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood flow redistribution in order to maintain delivery of oxygenated blood to the brain.
Patricia Garcia-Canadilla +7 more
doaj +1 more source
Circulating soluble endoglin and placental abruption [PDF]
Prenatal Diagnosis, 2008 AbstractObjectiveOur objective was to investigate whether serum concentrations of a novel anti‐angiogenic factor, soluble endoglin (sEng), could predict placental abruption.MethodsIn a nested case–control study of nulliparous pregnancies, we examined levels of sEng in serum collected prospectively from 31 women who later developed placental abruption ...
Caroline, Signore +6 more
openaire +2 more sources
Effects of maternal smoking on human placental vascularization: A systematic review
Taiwanese Journal of Obstetrics & Gynecology, 2019 The abnormal development of placental vascularization leads to placental insufficiency, which further reduces the nutrient and trace exchange between maternal circulation and fetal circulation. These changes cause maternal and fetal complications.
Daniela Pintican +3 more
doaj +1 more source
Bioengineering & Translational Medicine, 2023 Placental villi play a vital role in human fetal development, acting as the bridge of material exchange between the maternal and fetal. The abnormal morphology of placental villi is closely related to placental circulation disorder and pregnancy ...
Guangming Ni +8 more
doaj +1 more source
Assessment of the human placental microbiome in early pregnancy
Frontiers in Medicine, 2023 IntroductionBacteria derived from the maternal circulation have been suggested to seed the human placenta during development leading to an intrinsic placental microbiome. This concept has become controversial as numerous studies suggest that the apparent
Vassilena Sharlandjieva +3 more
doaj +1 more source