Results 71 to 80 of about 404,483 (304)

Characterisation of gold from Fiji [PDF]

open access: yes, 1995
This is a study of the variation in chemistry and inclusion mineralogy of bedrock and placer gold from Fiji. It forms part of a large project, undertaking gold characterisation from a wide range of geological environments in Ecuador, Zimbabwe ...
Henney, P.J., Naden, Jon
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Significados de la actividad física en la cotidianidad. Los lugares de la belleza y el placer en una práctica de salud

open access: yesRevista Ciencias de la Salud, 2019
Introducción: la visión de la actividad física como experiencia cotidiana, determinada en parte por la organización social, es importante para entender y promover su práctica, dados los beneficios en salud que conlleva.
Claudia Milena Hormiga Sánchez, PhD   +2 more
doaj   +1 more source

Explorable and economically attractive mineral deposits in the Siberian and Far Eastern Federal Districts of Russia [PDF]

open access: yes, 2018
Purpose. Selection of the most explorable mineral deposits in the Siberian and Far Eastern Federal Districts of the Russian Federation as investment projects. Methods.
Boyarko, G
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Transforma la norma, mujer descubre tu placer : campaña de educación sexual enfocada al placer femenino [PDF]

open access: yes, 2017
In the country, there is no sex education for women that includes pleasure in their pensum. After research, this campaign seeks first to create safe spaces to address the issue of female pleasure; to teach universal sexual rights and finally raising ...
Morejón Iglesias, Samia Alejandra   +1 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Complejidad del dolor y el sufrimiento humano

open access: yesRevista Latinoamericana de Psicopatologia Fundamental
En el presente trabajo se discute una cierta concepción unidireccional que, desde el positivismo lógico, se ha venido imponiendo en la investigación médico-psiquiátrica.
Carlos Rojas Malpica   +2 more
doaj   +1 more source

Confesiones de un cuerpo salvaje. Dame placer, de Flavia Company [PDF]

open access: yes, 2008
En este artículo llevo a cabo un análisis de Dame placer (1999), de la escritora Flavia Company, novela confesional en cuyas páginas se de-construye y re-construye una relación amorosa en la que se establece, mediante elementos que van más allá de la ...
Gutiérrez, Eva
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy