Results 131 to 140 of about 313,977 (292)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Geology and formation of titaniferous placer deposits in Upper Jogaz Valley area, Fanuj, Sistan and Baluchestan province, Iran

open access: yesJournal of Economic Geology, 2015
Introduction The Fanuj titaniferous placer deposits are located 35 km northwest of the Fanuj, Sistan and Baluchestan province (1) . The studied area comprises a (2) small part of the late Cretaceous Fanuj-Maskutan (Rameshk) ophiolite complex (Arshadi ...
Seyed Javad Moghaddasi, Javad Yazdi
doaj  

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Relief of island Sri Lanka (south-western part) and placers

open access: yesRUDN Journal of Engineering Research, 2009
On the explored territory 5 genetic types of the relief are distinguished as well as related to them gem sands. These gem sands had been formed in the Kalu-Ganga river valley within the junction zone of the low accumulative plain-depression and low hill ...
G N Kolosova   +3 more
doaj  

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