Results 81 to 90 of about 10,458 (283)
GeoresursyThe article identifies the problem of the need to take into account micro- (1 mm to 0.12 microns) and nanoscale (<0.12 microns) gold in placers and weathering crusts in order to increase the objectivity of their and eroded ore objects potential ...
I. V. Kuznetsova, A. I. Dementienko
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Hydraulic borehole mining method possible application at Middle Larba alluvial gold field
E3S Web of Conferences, 2018 Gold on placer deposits is mainly extracted in two ways: open and underground. But the open method of mining has a great negative impact on the environment, and the mine method is characterized by high labor intensity, capital and operating costs.
Rochev Vikror
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Optimal linear optical implementation of a single-qubit damping channel
, 2011 We experimentally demonstrate a single-qubit decohering quantum channel using linear optics. We implement the channel, whose special cases include both the amplitude-damping channel and the bit-flip channel, using a single, static optical setup ...
Fisher, Kent +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Editorial: Valve Virtuosi and Pacer Placers - Reducing the Need for Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement. [PDF]
Struct Heart, 2022 Kleiman NS.
europepmc +1 more source
Evolution of ideas about the origin of fossil resins
Мінеральні ресурси України, 2017 The paper deals with evolution of ideas about the origin of fossil resins as physically and chemically individualized organic compounds – products of natural processes in the Earth’s crust, biogenic origin and noncrystalline structure.
M. A. Bogdasarov, H. I. Rudko
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