Results 31 to 40 of about 94,492 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Impact of the Present-Day Climate Changes on the Natural Plague Foci Condition, Situated in the Territory of the Russian Federation and Other CIS Countries

Проблемы особо опасных инфекций, 2013
Climate changes determine dynamics of epizootic activity of natural plague foci in the XX and XXI centuries. Obvious shift to continentality in the Northern hemisphere can put an end to inter-epizootic period in lowland steppe and semi-desert natural ...
N. V. Popov, V. E. Bezsmertny, A. I. Udovikov, A. A. Kuznetsov, A. A. Sludsky, A. N. Matrosov, T. V. Knyazeva, Yu. M. Fedorov, V. P. Popov, A. K. Grazhdanov, T. Z. Ayazbaev, S. A. Yakovlev, T. B. Karavaeva, V. V. Kutyrev   +13 more
doaj   +1 more source

Crisis as a plague on organisation: Defoe and A Journal of the Plague Year [PDF]

, 2019
Purpose – The purpose of this paper is to enrich the understanding of current models of organisational response to crises and offer additional perspectives on some of these models.
Knowles, D., Ruth, D., Hindley, C.
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Global evolution and phylogeography of Brucella melitensis strains

BMC Genomics, 2018
Background Brucellosis is a bacterial zoonotic disease. Annually in the world more than 500,000 new cases of brucellosis in humans are registered. In this study, we propose an evolutionary model of the historical distribution of B.
Sergey V. Pisarenko, Dmitry A. Kovalev, Anna S. Volynkina, Dmitry G. Ponomarenko, Diana V. Rusanova, Nina V. Zharinova, Anna A. Khachaturova, Lyudmila E. Tokareva, Irina G. Khvoynova, Alexander N. Kulichenko   +9 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

The Review of Anthrax Situation 2013, the Forecast for 2014

Проблемы особо опасных инфекций, 2014
The analysis of epidemiological and epizootiological situation on anthrax in the Russian Federation and in the world in 2013 is carried out. The forecast of disease for 2014 is presented. Anthrax morbidity in humans in Russia is shown to decrease in 2013
A. G. Ryazanova, E. I. Eremenko, N. P. Buravtseva, L. U. Aksenova, O. I. Tsygankova, E. A. Koteneva, T. M. Golovinskaya, V. V. Voropaev, O. V. Pluzhnikova, A. N. Kulichenko   +9 more
doaj   +1 more source

Assessment of the Application of Erythrocytal Diagnosticum (Lyophilizate) in Detecting Tularemia Agent in Natural Foci

Проблемы особо опасных инфекций, 2022
Tularemia is a zoonotic disease with a wide geographical dissemination, and its causative agent Francisella tularensis can be used as a bioterrorism agent. The aim of the study was to evaluate the use of a set of reagents “Erythrocytic immunoglobulin dry
A. G. Koshkid’ko, S. A. Kurcheva, I. V. Zharnikova, A. A. Zaitsev, O. A. Gnusareva, O. L. Startseva, A. Yu. Gazieva, E. V. Zhdanova, T. V. Zharnikova, D. V. Rusanova   +9 more
doaj   +1 more source

Understanding the Stochastic Nature of Process Parameter Development of Blown Powder Laser Beam Directed Energy Deposition Additive Manufacturing of Pure Molybdenum

Advanced Engineering Materials, EarlyView.
Identified through the use of statistical design of experiments and metallographic investigation, this study exposes the stochastic origins of intergranular cracks in blown powder laser beam directed energy deposition additive manufacturing of pure molybdenum. It further demonstrates a successful crack mitigation approach with direct correlation to the
Nathaniel J. Lies, Daniel E. Driemeyer, Aaron P. Stebner   +2 more
wiley   +1 more source