Results 81 to 90 of about 70,641 (277)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Becoming a Lean University: the case of the University of St Andrews [PDF]

, 2015
This article looks at how “lean” can be successfully introduced into a higher education setting by discussing what has become known as ‘The St Andrews Model’.
Robinson, Mark, Yorkstone, Steve
core  

A systematic literature review of the use of social media for business process management [PDF]

, 2018
In today’s expansion of new technologies, innovation is found necessary for organizations to be up to date with the latest management trends. Although organizations are increasingly using new technologies, opportunities still exist to achieve the ...
A Looy Van, A Looy Van, A Looy Van, AM Kaplan, AM Nascimento, J vom Brocke, J vom Brocke, J vom Brocke, JH Kietzmann, M Dumas, M Fuduric, MM Choudhury, N Cook, O Blanchard, P Greenberg, RW Helms, S Erol, SK Boell, WG Mangold   +18 more
core   +1 more source

Continuous Improvement in Process Safety Education

Chemical Engineering Transactions, 2019
The importance of continuous improvement is emphasized in this paper from the perspectives of process safety education in general and university process safety courses in particular.
Paul Amyotte, Faisal Khan, Yene Irvine
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The new challenges of the manufacturing industry applying the norm ISO 45001:2018 [PDF]

, 2019
The present work reflects the impact that the manufacturing industries must solve in the application of the ISO 45001: 2018 Standard on Occupational Health and Safety Management Systems. In such, a globalized market where human and material assets must
Cano-Iglesias, Maria Jose, Cañero, Juan Miguel, Solano-Martos, Jose Francisco   +2 more
core  

Model of Arabic Language Learning Management in Child-Friendly Schools for the Development of Character Education in the Independent Curriculum

Jurnal Al Bayan: Jurnal Jurusan Pendidikan Bahasa Arab
A collegial management model was used in the implementation of the Child-Friendly School (CFS) policy at MIN 1 Mataram in developing character education in the Independent Curriculum, which has implications for Arabic learning management.
Nasarudin Nasarudin, Nurjannah Nurjannah, Muhirdan Muhirdan, Ahmad Helwani Syafii, Husnan Husnan, Henny Marlina   +5 more
doaj   +1 more source

Peningkatan dan Perbaikan dari Temuan Audit External ISO 9001 di LP3I College

Majalah Ilmiah Bijak, 2019
The findings of external audits in order to ensure the implementation of ISO 9001 quality management system at LP3I College for three consecutive years provide benefits in the form of improvement, correction  and consistency of the quality management ...
Wiwiet Prihatmadji
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source