Results 61 to 70 of about 51,837 (241)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Transforming Hospital Housekeeping: The Kayakalp Journey [PDF]

Global Journal on Quality and Safety in Healthcare
Introduction The Kayakalp guidelines for public healthcare facilities under the Swachh Bharat Abhiyan (Clean India Mission) focus on improving sanitation, cleanliness, and infection control at public hospitals in India.
Jawahar S.K. Pillai, Biswajeevan Sahoo, Mukunda Chandra Sahoo, Bijayini Behera, Renju Sussan Baby, Mariamma V. George, Jyotirmayee Rath, Chandramani Sahoo, Ashoka Mohapatra, Gaurav Chhabra, Binod Kumar Behera, Arvind Kumar Singh, Binod Kumar Patro, Ashok Kumar Jena   +13 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Application of the Plan–Do–Check–Act Cycle in Shortening the Decision to Delivery Interval Time

Risk Management and Healthcare Policy, 2022
Ming-Na Lu, Bai-Lei Zhang, Qiao-Hong Dai, Xian-Hu Fu Department of Obstetrics and Gynecology, Ningbo Women and Children’s Hospital, Ningbo, 315012, People’s Republic of ChinaCorrespondence: Qiao-Hong Dai, Department of Obstetrics and Gynecology, Ningbo ...
Lu MN, Zhang BL, Dai QH, Fu XH
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Advancing LEAN methodology adoption in Serbian manufacturing SMEs: empirical insights and a strategic implementation framework

Serbian Journal of Management
As manufacturing industries become more competitive around the world, Lean methodology must be used to improve operations and keep the market stable. However, small and medium-sized businesses (SMEs), have a hard time fully implementing Lean because they
Dragan Pavlović, Peđa Milosavljević, Milena Rajić, Zorana Stanković, Aleksandar Takači   +4 more
doaj   +1 more source

Effective Management of School Scouting Program by Applying Plan-Do-Check-Act Model

Psychology and Education Journal, 2021
Management of scouting program in schools appears to be challenging despite being a popular youth program that supports the holistic development of children and young people. This study identifies the importance of the school scouting program and reports the findings of a mixed mode study involving the development of guidelines to enhance effective ...
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source