Results 81 to 90 of about 51,850 (241)

Construction of a blended online and offline teaching quality assurance system for colleges based on “TQC+PDCA” [PDF]

SHS Web of Conferences
The PDCA (Plan-Do-Check-Act) method is a thinking approach and management procedure based on feedback loops, which can adapt to any management activity and has been successfully applied in many management fields.
Yin Yushi, Shen Jie, Zhang Min
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Lean on the shop floor: Reducing setup times on an automated packaging operation with the seven tools of quality: A case study [PDF]

Journal of Applied Research on Industrial Engineering
In today's competitive manufacturing environment, reducing setup times is critical for improving operational efficiency. This case study focuses on applying some of the Seven Tools of Quality (Cause-and-Effect diagram, Individuals and Moving Range (I-MR)
Robert Keyser, Valentina Nino
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Application of the Plan-Do-Check-Action Cycle in Reducing the Incidence of Forearm Hematoma in Patients After Transradial Artery Percutaneous Coronary Interventions

Journal of Multidisciplinary Healthcare
Yanqiu Fan, Xiaoyan Zhou Department of Cardiology, Jinhu County People’s Hospital, Huaian City, People’s Republic of ChinaCorrespondence: Xiaoyan Zhou, Department of Cardiology, Jinhu County People’s Hospital, Jiangsu Province, Huaian City, People’s ...
Fan Y, Zhou X
doaj  

Model of Arabic Language Learning Management in Child-Friendly Schools for the Development of Character Education in the Independent Curriculum

Jurnal Al Bayan: Jurnal Jurusan Pendidikan Bahasa Arab
A collegial management model was used in the implementation of the Child-Friendly School (CFS) policy at MIN 1 Mataram in developing character education in the Independent Curriculum, which has implications for Arabic learning management.
Nasarudin Nasarudin, Nurjannah Nurjannah, Muhirdan Muhirdan, Ahmad Helwani Syafii, Husnan Husnan, Henny Marlina   +5 more
doaj   +1 more source

MENIMBANG KUALITAS PENDIDIKAN ISLAM DAN KOMPETENSI MANAJERIAL KEPALA SEKOLA

Al-Misbah: Jurnal Islamic Studies, 2019
The quality of educational institutions will not be separated from the quality and managerial competence of the leadership of the institution. The more competent and professional managerial, a principal will bring an effect on the quality of the ...
Een Solihah
doaj   +1 more source