Results 61 to 70 of about 12,774 (254)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
PROJECT BASED ORGANIZATION - AN INTEGRATED APPROACH [PDF]
Management & Marketing, 2011 As a consequence of globalization, application of new technologies, turbulent economic environment, the uncertainties affecting markets, organizations must cope with ongoing transformational process.
Claudiu George BOCEAN
doaj
IMPROVING DATA MANAGEMENT FOR ENVIRONMENTAL REPORTING IN THE GOLD MINING INDUSTRY
South African Journal of Industrial Engineering, 2019 Environmental reporting is a realistic alternative for mines to prioritise operational changes in crucial environmental areas. Gold mines report to multiple platforms – i.e., integrated reporting.
Janse van Rensburg, Hendrika Magdalena Maryke +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Jurnal Al Bayan: Jurnal Jurusan Pendidikan Bahasa ArabA collegial management model was used in the implementation of the Child-Friendly School (CFS) policy at MIN 1 Mataram in developing character education in the Independent Curriculum, which has implications for Arabic learning management.
Nasarudin Nasarudin +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Pooled Vaccine Communication Actions to Promote Vaccination in the European Union: The Case of Italy
Journal of Primary Care & Community HealthIntroduction: Under the mandate of supporting European immunisation cooperation and strategies, the specific aim of this work was about focusing on vaccine communication in order to raise awareness, increase confidence and strengthen the practice for ...
Valentina Possenti +13 more
doaj +1 more source
Measurement loop, automatic tuning and product quality tracking
MATEC Web of Conferences, 2018 Starting from the PDCA cycle (Plan - Do - Check - Act), imposed by the ISO 9000 quality standards, a loop is proposed to automatically adjust the work equipment to the statistical distribution of the quality feature of the last N products randomly ...
Man Dietrich Marcela, Popa Marcel Sabin
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source