Results 121 to 130 of about 64,590,104 (297)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Bien communiquer sur sa thèse, suite.
EspacesTemps.net, 2005 Après une brève présentation sur lui-même, Edouard Paulino du Craft (Centre de recherche et d’appui pour la formation et ses technologies, qui travaille à l’ Epfl ) lance le débat : que signifie communiquer sur sa thèse ?
Philippe Heller
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Médiations & MédiatisationsEn France, les INSPÉ (Instituts nationaux supérieurs du professorat et de l’Éducation) forment les étudiants aux métiers du professorat, de l’éducation et de la formation.
Léa Degeuse, Alain Sénécail
doaj +1 more source
, 2012 This paper describes two experiments designed to ascertain whether the way in which architectural plans are displayed on a computer screen influences the quality of their correction by humans, and identify the visual exploration strategies adopted in this type of task.
Fleury, Sylvain, Jamet, Eric
openaire +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Une gestion globale et solidaire des paysages de la Sèvre Nantaise
Sciences, Eaux & Territoires, 1997 La Sèvre Nantaise est un affluent de la rive gauche de la Loire. Au carrefour de l'Anjou, de la Bretagne et du Poitou, les paysages qu'elle anime sont diversifiés tout en étant unis par une dominante bocagère au relief faiblement accentué.
M.A. RANNOU
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