Results 171 to 180 of about 149,597 (269)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multifunctional Activity of <i>Lippia gracilis</i> Schauer Essential Oil Against Skin Infections. [PDF]

Plants (Basel)
Soares IL, Sá K, Canuto KM, Bandeira MA, Salgueiro L, Zuzarte M.   +5 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis. [PDF]

EMBO Rep
Artes MH, Iacobucci S, Barallobre MJ, Carballeira P, Garcia-Cajide M, Pérez-Venteo A, Padilla N, Viegas BS, Díaz-Vásquez A, Nacht AS, Vicent GP, Arbonés ML, de la Cruz X, Nieto M, Agell N, Mauvezin C, Martínez-Balbás MA.   +16 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Integrating Single-Cell Profiling with Generative AI for <i>De Novo</i> Design of MMP9 Protein Binders in Diffuse Large B-Cell Lymphoma. [PDF]

Molecules
Miao Z, Zhu S, Qin L, Ma D, Lai M, Xu P, Jin Y, Cai H, Zhao S, Wang Y.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

White Grape Cell Walls as Fining Agents in Red Wine: Mechanistic Insights from ATR-FTIR Spectroscopy. [PDF]

Foods
Gómez-Pérez J, Baca-Bocanegra B, Hernández-Hierro JM, Beć KB, Huck CW, Nogales-Bueno J.   +5 more
europepmc   +1 more source

Plan d'études d'un cours de formation pour tuteurs

, 1999
Braga, Fátima, Fonseca, Fernanda Irene
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source