Results 231 to 240 of about 64,590,104 (297)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Processus de préparation des cytotoxiques injectables : gestion des risques par l’application de la méthode d’analyse des modes de défaillance, de leurs effets et de leur criticité. [PDF]

Can J Hosp Pharm
Ben Ayed W, Ben Haddada A, Ben Said A, Toukabri I, Limayem I.   +4 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Lanthanide-Dependent Self-Assembly of Ion-Extractant Complexes at Liquid Interfaces: Inversion or Exclusion? [PDF]

J Phys Chem B
Sun P, Premadasa UI, Walwark D, Bu W, Doughty B.   +4 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Complete genome sequences of the biocontrol strains <i>Bacillus velezensis</i> MRL14-522 and MRL14-108. [PDF]

Microbiol Resour Announc
Grimonpont M, Turc E, Monnier N, Bardin M.   +3 more
europepmc   +1 more source

Proposition de plan pour un module de formation : Transition juste et équité sociale.

Les cahiers de pédagogies radicales
openaire   +1 more source

Refonder l’enseignement du latin : Plan National de Formation, 11 octobre 2013

La question du latin, 2013
openaire   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Envisioning family, but where? Parenthood-related geographic preferences among childless LGB and heterosexual adults in Ecuador. [PDF]

Front Sociol
Hermosa-Bosano C, Hidalgo-Andrade P, Borja-Moreano R, Parra-Gaete C.   +3 more
europepmc   +1 more source