Results 81 to 90 of about 146,810 (268)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

De quelques points de vue sur la formation de chercheurs amérindiens au Brésil

Nuevo mundo - Mundos Nuevos, 2017
Cette communication traitera en premier lieu des multiples formats adoptés au Brésil pour la formation de chercheurs amérindiens, en s’interrogeant sur les modes amérindiens de contrôler la recherche, la production et la circulation de connaissances ...
Dominique Tilkin Gallois
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Quels savoirs pour l’enseignement du français dans les plans de formation suisses romands ?

Repères, 2011
Partie d’un projet plus large sur les pratiques de formation à l’enseignement de la production écrite, cette contribution vise à comprendre les facteurs et contraintes contextuelles influençant les institutions de formation primaire en Suisse romande. Plus particulièrement, il s’agit de situer la didactique du français dans le fonctionnement global de ...
Roxane Gagnon, Marc Surian, null FAPSE
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Problématiser le rôle de la technique et de l’individuation pour faire face aux enjeux de numérisation des situations d’enseignement dans une perspective de Lifelong learning

Médiations & Médiatisations
Le travail dans le champ de la formation des enseignants se numérise et l’accès facilité aux intelligences artificielles génératives ouvrent de nouveaux possibles.
Gaëlle Martin, Nicolas Perrin, Laura Vita, David Piot, Joëlle Ambrosini   +4 more
doaj   +1 more source

Ipotecare il futuro. Le basi democratiche della Repubblica nel pensiero e nell’azione di Giustizia e Libertà e del Partito d’Azione

Laboratoire Italien, 2012
Les « giellistes » (les membres du mouvement Giustizia e Libertà) s’étaient persuadés, après la crise de 1929 et au début des années trente, de la nécessité de l’intervention de l’État dans l’économie.
Leonardo Casalino
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source