Results 211 to 220 of about 141,844 (268)

RBM10 modulation of circRNA biogenesis contributes to its tumor suppressor role in lung adenocarcinoma. [PDF]

Biomark Res
Utrilla-Maestre A, Matia-González AM, Peinado P, Becerra-Rodriguez MA, Benitez-Cantos MS, Cuadros M, Medina PP.   +6 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

2D Assemblies Based on a Tetraphenylethylene D,L-Cyclic Peptide Scaffold. [PDF]

Angew Chem Int Ed Engl
Bayón-Fernández A, Torrón-Celada A, Méndez-Ardoy A, Coste M, Delgado-Gestoso D, Ulrich S, Montenegro J, Granja JR.   +7 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effect of a chiral dopant on hysteresis phenomena induced by external fields in liquid crystals. [PDF]

Sci Rep
Lacková V, Makarov DV, Petrov DA, Tóth-Katona T, Kónyová K, Kopčanský P, Tomašovičová N.   +6 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A novel pathogenic variant in PSTPIP1 highlights the diversity of PSTPIP1-associated disorders. [PDF]

Rheumatology (Oxford)
Farajzadeh N, Triaille C, Monjarret B, Lamothe S, Touzot F, Cros G.   +5 more
europepmc   +1 more source

Un exemple d’ingénierie psychosociale : l’évaluation du plan de formation des cadres du ministère de la Justice

, 1994
Chapet, Pierre-Alain, Dreff, Gwenaelle Le, Poultier, François Le   +2 more
openaire   +1 more source

Expression and clinical significance of growth differentiation factor-15 in vascular cognitive impairment based on bioinformatic analysis. [PDF]

J Transl Int Med
Lin J, Mao N, Wu Z, Yang R, Zhang Y, Ge Y.   +5 more
europepmc   +1 more source

Substrate-Selective Temperature-Controlled Synthesis of Thiophene Derivatives at Interfaces. [PDF]

Angew Chem Int Ed Engl
Pérez-Elvira E, Barragán A, Vicent DJ, Jóver Ó, Gallardo A, García-Frutos A, Černa L, Lauwaet K, Santos J, Perles J, Gallego JM, Miranda R, Urgel JI, Björk J, Di Giovannantonio M, Martín N, Écija D.   +16 more
europepmc   +1 more source