Results 251 to 260 of about 1,593,802 (309)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Facteurs influençant l'implantation d'un programme de prévention universelle de l'anxiété : le cas du programme HORS-PISTE dans les écoles secondaires du Québec. [PDF]

Glob Health Promot
Lane J, Houle AA, Therriault D, Dupuis A, Tougas AM, Saint-Pierre Mousset E.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

New Insights into the Molecular Actions of Grosheimin, Costunolide, and α- and β-Cyclocostunolide on Primary Cilia Structure and Hedgehog Signaling. [PDF]

Int J Mol Sci
Murillo-Pineda M, Martínez-Miralles J, Medina-Calzada Z, Varela RM, Macías FA, Chinchilla N, Juárez-Soto Á, Santpere G, Reales E.   +8 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Vertebral artery stump syndrome after internal carotid artery stenting: A case report. [PDF]

Medicine (Baltimore)
Yin S, Zhu J, Fu G.
europepmc   +1 more source

Un exemple d’ingénierie psychosociale : l’évaluation du plan de formation des cadres du ministère de la Justice

, 1994
Chapet, Pierre-Alain, Dreff, Gwenaelle Le, Poultier, François Le   +2 more
openaire   +1 more source

Synthesis of Tronocarpine Framework via a Michael/Lactamization/Michael Cascade Process: Synthesis of Dihydrotronocarpine. [PDF]

J Org Chem
Castañón-Garcíaa M, Escalantea CH, Mirandaa LD.   +2 more
europepmc   +1 more source

Inactivation of Cysteine Synthase CysK-A enhances flocculation, biofilm formation, and sensitivity to oxidative stress in <i>Azospirillum brasilense</i> Sp7. [PDF]

Biofilm
Herrera-Galindo J, Alcantara-Rosales CA, Ojeda OM, Xiqui-Vázquez ML, Mancilla-Simbro C, Reyes-Carmona S, Baca BE, Ramírez-Mata A.   +7 more
europepmc   +1 more source