Results 51 to 60 of about 141,844 (268)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Modélisation du rôle des systèmes de valeurs dans la transition d’une identité de métier vers une nouvelle identité enseignante en formation professionnelle

Canadian Journal for New Scholars in Education, 2015
Les enseignants du secteur de la formation professionnelle au Québec se distinguent par leur recrutement et leur insertion dans la profession.
Andréanne Gagné
doaj  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Caractérisation multi-niveaux des verrous et leviers à la réduction d’usage des pesticides au Cameroun

Cahiers Agricultures
L’usage des pesticides, technologie peu onéreuse pour lutter contre les ennemis des cultures, est en pleine croissance dans l’agriculture africaine. Les pesticides sont pourtant source de nombreuses externalités négatives.
De La Paix Bayiha Gérard, Temple Ludovic, Jas Nathalie, Tata Ngome Precillia Ijang   +3 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

La interdisciplinariedad y la formación profesional: una reflexión desde la disciplina de física

Góndola, Enseñanza y Aprendizaje de las Ciencias, 2015
El sistema educativo universitario cubano se ha enfrentado a varios retos en la actualidad, uno de ellos es la interdisciplinariedad. Esta metodología dentro del proceso docente se considera imprescindible en los primeros años de cualquier carrera ...
Yaima Rodríguez Peña
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

La formation professionnelle comme accomplissement interactionnel et multimodal : le cas de l’apprentissage sur la place de travail

Scripta, 2011
L’objectif de cet article est de mieux comprendre comment des jeunes adultes en formation professionnelle initiale sont accompagnés par des travailleurs experts dans des situations pratiques de travail en entreprise.
Laurent Filliettaz
doaj