Results 111 to 120 of about 62,890,502 (300)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Plan regional de desarrollo del sector agropecuario de la IV region: Anexos
, 1977 Este documento, contiene los anexos del Plan regional de desarrollo del sector agropecuario de la IV region, los cuales abarca la situación actual y perspectiva de la región en relación a los problemas originados por la escasez de agua; los aportes del ...
Momberg, Alfonso +3 more
core
Plan de aforos. Red secundaria 2000: Jaén
, 2001 Andalucía. Consejería de Obras Públicas y Transportes; Andalucía. Dirección General de Carreteras; Andalucía. Servicio de Explotación y TecnologíaContiene: Mapa red secundaria 2000.
Andalucía. Consejería de Obras Públicas y Transportes +2 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Bien communiquer sur sa thèse, suite.
EspacesTemps.net, 2005 Après une brève présentation sur lui-même, Edouard Paulino du Craft (Centre de recherche et d’appui pour la formation et ses technologies, qui travaille à l’ Epfl ) lance le débat : que signifie communiquer sur sa thèse ?
Philippe Heller
doaj
Médiations & MédiatisationsEn France, les INSPÉ (Instituts nationaux supérieurs du professorat et de l’Éducation) forment les étudiants aux métiers du professorat, de l’éducation et de la formation.
Léa Degeuse, Alain Sénécail
doaj +1 more source
, 2012 This paper describes two experiments designed to ascertain whether the way in which architectural plans are displayed on a computer screen influences the quality of their correction by humans, and identify the visual exploration strategies adopted in this type of task.
Fleury, Sylvain, Jamet, Eric
openaire +1 more source