Results 71 to 80 of about 146,810 (268)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Scripta, 2011 L’objectif de cet article est de mieux comprendre comment des jeunes adultes en formation professionnelle initiale sont accompagnés par des travailleurs experts dans des situations pratiques de travail en entreprise.
Laurent Filliettaz
doaj
Ensaio, 2012 Este trabalho analisa a política de regulação do Plano de Desenvolvimento da Educação (PDE) considerando as ações do Plano de Ações Articuladas (PAR) como indutoras de melhoria da qualidade na educação básica.
Marilda Pasqual Schneider +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Mejora continua de la calidad en una unidad médica de valoración de incapacidad temporal
Medicina y Seguridad del Trabajo, 2007 Objetivo: Nuestro objetivo es el diseño de un plan de mejora continua de la calidad en una Unidad Medica de Valoración de Incapacidades (UMVI). Métodos: La metodología utilizada sigue las directrices marcadas por la Consejería de Salud, en cuanto a ...
Esther Álvarez Theurer +1 more
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LES SCIENCES DE L’INFORMATION DOCUMENTAIRE A L’AUBE DE SES 5O EN RDC : ESSAI D’UN BILAN A L’INSTITUT SUPERIEUR DE STATISTIQUE DE KINSHASA « ISS-KIN » [PDF]
ZiglôbithaRésumé : L’Institut Supérieur de Statistique de Kinshasa à travers son département de sciences et techniques documentaires est la première école d’enseignement supérieur en Afrique Centrale a formé dans le domaine de l’archivistique, de la ...
Olivier LONGI NZASI
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source