Results 51 to 60 of about 775,463 (344)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Design of Wideband Microstrip to SICL Transition for Millimeter-Wave Applications

IEEE Access, 2020
In this communication, the design and working principle of a wideband microstrip to substrate integrated coaxial line (SICL) planar transition for millimeter-wave applications is presented.
Idury Satya Krishna, Soumava Mukherjee
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

On Planar Supports for Hypergraphs [PDF]

Journal of Graph Algorithms and Applications, 2010
A graph G is a support for a hypergraph H=(V,S) if the vertices of G correspond to the vertices of H such that for each hyperedge Si e S the subgraph of G induced by Si is connected. G is a planar support if it is a support and planar. Johnson and Pollak [9] proved that it is NP-complete to decide if a given hypergraph has a planar support. In contrast,
Kevin Verbeek, Marc van Kreveld, Henk Meijer, Kevin Buchin, Bettina Speckmann   +4 more
openaire   +8 more sources

A note on comaximal ideal graph of commutative rings

AKCE International Journal of Graphs and Combinatorics, 2020
Let be a commutative ring with identity. The comaximal ideal graph of is a simple graph with its vertices are the proper ideals of R which are not contained in the Jacobson radical of , and two vertices and are adjacent if and only if .
S. Kavitha, R. Kala
doaj   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Method of calculating the parameters of ultrasonic super-high-frequency transducers

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2013
The paper presents a method of calculating the parameters of half-wave package ultrasonic piezoelectric emitters and step waveguides, which has an error no more than 6—8%.
V. L. Lanin, I. B. Petukhov
doaj  

The Existence of Planar Hypotraceable Oriented Graphs [PDF]

Discrete Mathematics & Theoretical Computer Science, 2017
A digraph is \emph{traceable} if it has a path that visits every vertex. A digraph $D$ is \emph{hypotraceable} if $D$ is not traceable but $D-v$ is traceable for every vertex $v\in V(D)$.
Susan van Aardt, Alewyn Petrus Burger, Marietjie Frick   +2 more
doaj   +1 more source

3D MRI Tract‐Specific Spinal Cord Lesion Pattern Improves Prediction of Distinct Neurological Recovery

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To distinguish lateralized motor‐ and sensory‐tract damage after acute spinal cord injury (SCI) and explore its predictive power for motor and sensory recovery. Methods Thirty‐five SCI patients (two female) from a multi‐center data set (placebo‐arm of the Nogo‐A‐Inhibition in SCI trial) underwent routine T2‐weighted sagittal MRI ...
Lynn Farner, Tim M. Emmenegger, Simon Schading‐Sassenhausen, Julia Berroth, Maryam Seif, Armin Curt, Patrick Freund, The Nogo Inhibition in Spinal Cord Injury Study Group   +7 more
wiley   +1 more source