Results 51 to 60 of about 85,433 (291)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Easily retrievable objects among the NEO population [PDF]

, 2013
Asteroids and comets are of strategic importance for science in an effort to understand the formation, evolution and composition of the Solar System. Near-Earth Objects (NEOs) are of particular interest because of their accessibility from Earth, but also
C Simó, C Zagouras, C. R. McInnes, D. García Yárnoz, DL Richardson, DR Adamo, E Belbruno, E Canalias, G Gómez, G Gómez, G Tancredi, H-X Baoyin, J Kawaguchi, J. P. Sanchez, JP Sanchez, KC Howell, KC Howell, LA Kleiman, M Granvik, M Hénon, M Vasile, P Michel, P Veres, PW Chodas, R Brasser, S Greenstreet, SR Chesley, T Kwiatkowski, TL Edward, V Szebehely, WS Koon, Z Hasnain   +31 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Acoustic analogues of black hole singularities

, 2005
We search for acoustic analogues of a spherical symmetric black hole with a pointlike source. We show that the gravitational system has a dynamical counterpart in the constrained, steady motion of a fluid with a planar source. The equations governing the
A. Gullstrand, G. E. Volovik, M. Novello, Mariano Cadoni, P. Painlevé, S. Weinberg, Salvatore Mignemi   +6 more
core   +1 more source

Dynamic Analysis for Planar Multibody Mechanical Systems with Lubricated Joints [PDF]

Multibody System Dynamics, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Flores, Paulo, Ambrósio, Jorge, Claro, José Carlos Pimenta   +2 more
openaire   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

On two-dimensional superpotentials: from classical Hamilton-Jacobi theory to 2D supersymmetric quantum mechanics

, 2004
Superpotentials in ${\cal N}=2$ supersymmetric classical mechanics are no more than the Hamilton characteristic function of the Hamilton-Jacobi theory for the associated purely bosonic dynamical system.
A Alonso Izquierdo, Abramowitz M, Andrianov A, Andrianov A, Andrianov A, Andrianov A Ioffe M Nishnianidze D, Cannata F, Casalbuoni R, Cooper F, Heumann R, J Mateos Guilarte, Junker G, Liouville J, M A Gonzalez Leon, M de la Torre Mayado, Pauling L, Perelomov A, Witten E   +17 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Dynamical analysis and the soliton solutions of (2+1)-dimensional Heisenberg ferro-magnetic spin chains model with beta fractional derivative

Scientific Reports
This paper investigates the soliton solutions and dynamical analysis of (2+1)-dimensional Heisenberg ferro-magnetic spin chains model with beta fractional derivative, which is transformed into the ordinary differential equation. By using the second-order
Jie Luo
doaj   +1 more source

Orbital dynamics in the planar Saturn-Titan system [PDF]

Astrophysics and Space Science, 2015
We use the planar circular restricted three-body problem in order to numerically investigate the orbital dynamics of orbits of a spacecraft, or a comet, or an asteroid in the Saturn-Titan system in a scattering region around the Titan. The orbits can escape through the necks around the Lagrangian points $L_1$ and $L_2$ or collide with the surface of ...
openaire   +2 more sources