Results 61 to 70 of about 82,884 (244)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
3-Facial Coloring of Plane Graphs [PDF]
SIAM Journal on Discrete Mathematics, 2008 A plane graph is l-facially k-colourable if its vertices can be coloured with k colours such that any two distinct vertices on a facial segment of length at most l are coloured differently. We prove that every plane graph is 3-facially 11-colourable.
Havet, Frédéric +2 more
openaire +3 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Edge looseness of plane graphs
Ars Mathematica Contemporanea, 2015 A face of an edge colored plane graph is called e-loose if the number of colors used on its edges is at least three. The e-looseness of a plane graph G is the minimum positive integer k such that any edge coloring of G with k colors involves an e-loose face.
openaire +3 more sources
A plane graph representation of triconnected graphs
Theoretical Computer Science, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ota, Shunsuke +2 more
openaire +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Graphs embedded into finite projective planes
Contributions to Discrete Mathematics, 2015 We study embeddings of graphs in finite projective planes, and present related results for some families of graphs including complete graphs and complete bipartite graphs. We also make connections between embeddings of graphs and the existence of certain substructures in a plane, such as Baer subplanes and arcs.
Mellinger, Keith +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Discrete Mathematics, Algorithms and ApplicationsA graph is called NIC-planar if it admits a drawing in the plane such that each edge is crossed at most once and two pairs of crossing edges share at most one vertex. A graph together with a NIC-planar drawing is a NIC-plane graph. A graph is maximal NIC-planar or NIC-plane, if we cannot add any missing edge so that the resulting graph is still NIC ...
Ding, Zongpeng +2 more
openaire +3 more sources