Results 71 to 80 of about 2,666,039 (345)
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
No finite $5$-regular matchstick graph exists [PDF]
, 2014 A graph $G=(V,E)$ is called a unit-distance graph in the plane if there is an injective embedding of $V$ in the plane such that every pair of adjacent vertices are at unit distance apart.
Kurz, Sascha
core
Infinitesimal rigidity in normed planes
, 2018 We prove that a graph has an infinitesimally rigid placement in a non-Euclidean normed plane if and only if it contains a $(2,2)$-tight spanning subgraph.
Dewar, Sean
core +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
On Partitioning the Edges of 1-Plane Graphs
, 2016 A 1-plane graph is a graph embedded in the plane such that each edge is crossed at most once. A 1-plane graph is optimal if it has maximum edge density.
Lenhart, William J. +2 more
core +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
On building 4-critical plane and projective plane multiwheels from odd wheels [PDF]
, 2012 We build unbounded classes of plane and projective plane multiwheels that are 4-critical that are received summing odd wheels as edge sums modulo two. These classes can be considered as ascending from single common graph that can be received as edge sum ...
Zeps, Dainis
core +2 more sources
Every Graph Is an Integral Distance Graph in the Plane
Journal of Combinatorial Theory, Series A, 1997 For a finite subset of the plane the pairs of points for which their euclidean distance is an integer defines the corresponding integral distance graph. It is shown that every finite simple graph may be represented in such a way.
Norihide Tokushige +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source