Results 91 to 100 of about 2,427,282 (299)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Journal of Combinatorial Theory, Series B, 1983 AbstractIt is proven that, if Γ0 and Γ1 are isomorphic strictly convex graphs such that their outer polygons correspond to each other and have the same orientations, then Γ0 can be continuously deformed into Γ1 such that, at each stage, the graph under consideration is convex. This extends a result of Cairns (Ann of Math.
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
New Results of Face Labeling for Some Plane Graphs
IEEE Access, 2019 A labeling of a plane graph is called super d-antimagic if the vertices receive the smallest labels and the weight set of all faces in an arithematic progression with difference d, where weight of each face is the some of all labels correspond to that ...
Nabila Hameed +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Approximate min-max relations on plane graphs
Journal of combinatorial optimization, 2013 Let G be a plane graph, let τ(G) (resp. τ′(G)) be the minimum number of vertices (resp. edges) that meet all cycles of G, and let ν(G) (resp. ν′(G)) be the maximum number of vertex-disjoint (resp. edge-disjoint) cycles in G. In this note we show that τ(G)
Jie Ma, Xingxing Yu, Wenan Zang
semanticscholar +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The structure of plane graphs with independent crossings and its applications to coloring problems
, 2013 If a graph G has a drawing in the plane in such a way that every two crossings are independent, then we call G a plane graph with independent crossings or IC-planar graph for short.
Xin Zhang, G. Liu
semanticscholar +1 more source