Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Dynamic Fracture Resistance under Plane Strain Conditions of High-Density Polyethylene Nanoclay Composites. [PDF]
Polymers (Basel), 2023 López-Cabrera HR +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Qualitative and Quantitative Investigations on the Failure Effect of Critical Fissures in Rock Specimens under Plane Strain Compression. [PDF]
Materials (Basel), 2023 Wen J, Tang L, Zhang S, Zhan Q, Wang Y.
europepmc +1 more source
Strong 4-mode coupling of nanomechanical string resonators
, 2017 We investigate mechanical mode coupling between the four fundamental flexural modes of two doubly-clamped, high-Q silicon-nitride nanomechanical string resonators.
Gajo, Katrin +2 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Microstructural and Textural Investigation of an Mg-Zn-Al-Ca Alloy after Hot Plane Strain Compression. [PDF]
Materials (Basel), 2022 Kittner K, Ullmann M, Prahl U.
europepmc +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Study of Thickness Effect on Fracture Toughness of High Grade Pipeline Steel
MATEC Web of Conferences, 2016 The critical fracture toughness decreases when thickness of specimens increases and stress-strain field in crack tip start changing to plane strain state from plane stress state. In this paper, fracture toughness tests were carried. Based on the analysis
Zhang Hua +4 more
doaj +1 more source
In-plane strain engineering in ultrathin noble metal nanosheets boosts the intrinsic electrocatalytic hydrogen evolution activity. [PDF]
Nat Commun, 2022 Wu G +9 more
europepmc +1 more source